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The Flavonoids Advances In Research Since 1980

This study aimed to study the impact of selected common organic solvents on extractable solids, phytochemical composition, and antioxidant capacity of S. chinensis. The results showed that the tested solvents played an important role in extraction of total solid and phytochemical composition as well as antioxidant capacity of S. chinensis. Acetone (50% v/v) was found to be the optimal extraction solvent for extractable solids (12.2%), phenolic compounds (60 mg GAE/g DW), flavonoids (100 mg CE/g DW), proanthocyanidins (47.4 mg CE/g DW), and saponins (754 mg EE/g DW) as well as antioxidant capacity (ABTS 334 mM TE/g DW, DPPH 470 mM TE/g DW, FRAP 347 mM TE/g DW, and CUPRAC 310 mM TE/g DW). The extract prepared from 50% acetone had high levels of bioactive compounds (TPC 555 mg GAE/g CRE, flavonoids 819 mg CE/g CRE, proanthocyanidins 392 mg CE/g CRE, and saponins 1,880 mg EE/g CRE) as well as antioxidant capacity (ABTS 414 mM TE/g, DPPH 407 mM TE/g, FRAP 320 mg TE/g, and CUPRAC 623 mM TE/g), thus further confirming that 50% acetone is the solvent of choice. Therefore, 50% acetone is recommended for extraction of phenolic compounds, their secondary metabolites, saponins, and antioxidant capacity from the root of S. chinensis for further isolation and utilisation.

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Impact of Different Extraction Solvents on Bioactive Compounds and Antioxidant Capacity from the Root of Salacia chinensis L.

In vitro evaluation of antioxidant and cytotoxic activities of lignin fractions extracted from Acacia nilotica

Objective: The objective of the present study was to determine the total content of phenolics and flavonoids in selected medicinal plants such as Atuna indica, Baliospermum montanum, Chukrasia tabularis, Humboldtia brunonis var. rakthapushpa and Soymida febrifuga. Methods: The total phenolic content (TPC) was estimated spectrophotometrically using Folin Ciocalteu method. Total flavonoid content (TFC) was measured by aluminium chloride colorimetric assay. Results: The results showed that Chukrasia tabularis (belonging to the family Meliaceae) is the richest source of phenolics and flavonoid (total Phenolic content: 17.2 mg GAE/g and total flavonoid content: 3.82 QE/g). The lowest phenolic content was noticed in Baliospermum montanum (2.72 mg GAE/g) and lowest flavonoid content was observed in Humboldtia brunoniss var. raktapushpa (0.98 mg QE/g). Conclusion: A significant linear correlation was observed between the values for the total phenolic content and antioxidant activity. The high contents of phenolic compounds indicated that these compounds contribute to the antioxidant activity. The Chukrasia tabularis can be regarded as promising plant species for natural plant sources of antioxidants with high potential value for drug preparation.

Total phenolics and flavonoids in selected medicinal plants from kerala

The current management of Alzheimer's disease (AD) focuses on acetylcholinesterase inhibitors (AChEIs) and NMDA receptor antagonists, although outcomes are not completely favorable. Hence, novel agents found in herbal plants are gaining attention as possible therapeutic alternatives. The Terminalia chebula (Family: Combretaceae) is a medicinal plant with a wide spectrum of medicinal properties and is reported to contain various biochemicals such as hydrolysable tannins, phenolic compounds, and flavonoids, so it may prove to be a good therapeutic alternative. In this research, we reviewed published scientific literature found in various databases: PubMed, Science Direct, Scopus, Web of Science, Scirus, and Google Scholar, with the keywords: T. chebula, AD, neuroprotection, medicinal plant, antioxidant, ellagitannin, gallotannin, gallic acid, chebulagic acid, and chebulinic acid. This review shows that T. chebula extracts and its constituents have AChEI and antioxidant and anti-inflammatory effects, all of which are currently relevant to the treatment of Alzheimer's disease.

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A Review on Potential Mechanisms of Terminalia chebula in Alzheimer's Disease.

Plant phenolics and flavonoids have a powerful biological activity, which outlines the necessity of their determination. The phenolics and flavonoids content of 20 medicinal plants were determined in the present investigation. The phenolic content was determined by using Folinâ??Ciocalteu assay. The total flavonoids were measured spectrophotometrically by using the aluminium chloride colorimetric assay. The results showed that the family Mimosaceae is the richest source of phenolics, (Acacia nilotica: 80.63 mg gallic acid equivalents, Acacia catechu 78.12 mg gallic acid equivalents, Albizia lebbeck 66.23 mg gallic acid equivalents). The highest total flavonoid content was revealed in Senna tora which belongs to the family Caesalpiniaceae. The present study also shows the ratio of flavonoids to the phenolics in each sample for their specificity.

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Total phenolics and total flavonoids in selected Indian medicinal plants.

The objective of the present study was to evaluate the radical scavenging and anti AChE activity of three Acacia species collected from south India. Ethanolic extracts of three Acacia species collected from South India were analyzed for their activity towards acetylcholinestrase (AChE) enzyme and their antioxidant activity. The antioxidant activity was evaluated using different in vitro techniques such as DPPH assay, NO quenching assay and ABTS assay. Anti-acetylcholinestrase activity was measured using Ellman;s method. The chemical profiling was done using HPLC. Most of the plant materials analyzed showed some inhibitory activity towards acetyl cholinesterase. Acacia catechu and Acacia leucophloea extracts were generally less potent. Acacia nilotica showed comparatively significant AChE activity. Acacia nilotica have good inhibitory properties and exhibited a dose dependent relationship (1 mgml−1, 27.65 %.; 5 mgml−1, 32.44 %; 15 mgml−1, 47.87%; 25 mgml−1 63.28 %). A. nilotica showed the highest NO quench...

Chromatographic Studies and in vitro Screening for Acetyl Cholinesterase Inhibition and Antioxidant Activity of three Acacia Species from South India

Phenolic characterisation of selected Salacia species using LC-ESI-MS/MS analysis

LC/MS characterization of phenolic antioxidants of Brindle berry (Garcinia gummi-gutta (L.) Robson)

Isolation and identification of phytoestrogens and flavonoids in an Ayurvedic proprietary medicine using chromatographic and Mass Spectroscopic analysis

C. T. Sulaiman

Papers

Total phenolics and total flavonoids in selected Indian medicinal plants.

Chromatographic Studies and in vitro Screening for Acetyl Cholinesterase Inhibition and Antioxidant Activity of three Acacia Species from South India

Phenolic characterisation of selected Salacia species using LC-ESI-MS/MS analysis

LC/MS characterization of phenolic antioxidants of Brindle berry (Garcinia gummi-gutta (L.) Robson)

Isolation and identification of phytoestrogens and flavonoids in an Ayurvedic proprietary medicine using chromatographic and Mass Spectroscopic analysis