Showing papers by "Calle Bengtsson published in 1972"
TL;DR: Follow‐up studies showed that the effect of alprenolol on the BP increased when the dosage was doubled, and in spite of the potassium substitution chlorthalidone reduced serum potassium significantly, while no change was found with alpRenolol.
Abstract: A double‐blind cross‐over study comparing alprenolol 100 mg × 4 with chlorthalidone 50 mg × 1 has been performed on 40 subjects. Throughout the study 1.5 g potassium chloride was given daily. In the dosages given both alprenolol and chlorthalidone caused a significant reduction of the BP. Chlorthalidone reduced the BP significantly more than alprenolol. Follow‐up studies showed that the effect of alprenolol on the BP increased when the dosage was doubled. In spite of the potassium substitution chlorthalidone reduced serum potassium significantly, while no change was found with alprenolol. There was a significant increase in serum uric acid with both alprenolol and chlorthalidone, being significantly more pronounced with chlorthalidone. Subjective side‐effects were few and transient both with alprenolol and chlorthalidone.
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