Camila López-Crisosto

TL;DR: It is demonstrated for the first time in knowledge that insulin acutely regulates mitochondrial metabolism in cardiomyocytes through a mechanism that depends on increased mitochondrial fusion, Opa-1, and the Akt-mTOR-NFκB pathway.

TL;DR: The mechanisms that coordinate mitochondrial and Ca2+ responses and how they affect human health are summarized.

TL;DR: Treatment of cultured neonatal rat cardiomyocytes with the hypertrophic agonist norepinephrine promotes mitochondrial fission and promotes a decrease in mitochondrial mean volume and an increase in the relative number of mitochondria per cell and the importance of mitochondrial dynamics in the development ofCardiomyocyte hypertrophy and metabolic remodeling is demonstrated.

TL;DR: The evidence related to the role of sarco/endoplasmic reticulum–mitochondria communication in cardiac and vascular muscle physiology is summarized, with a focus on how perturbations contribute to the pathogenesis of cardiovascular disorders.

TL;DR: Emerging data on how communication between endoplasmic reticulum and mitochondria can modulate organelle function and determine cellular fate are reviewed.