C
Carlos Eduardo Sampaio Guedes
Researcher at Oswaldo Cruz Foundation
Publications - 10
Citations - 350
Carlos Eduardo Sampaio Guedes is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Leishmania infantum & Leishmania mexicana. The author has an hindex of 6, co-authored 10 publications receiving 290 citations. Previous affiliations of Carlos Eduardo Sampaio Guedes include Federal University of Bahia.
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Journal ArticleDOI
Advances in Development of New Treatment for Leishmaniasis.
Juliana Perrone Bezerra de Menezes,Carlos Eduardo Sampaio Guedes,Antonio Luis de Oliveira Almeida Petersen,Deborah Bittencourt Mothé Fraga,Patrícia Sampaio Tavares Veras +4 more
TL;DR: How high-throughput analysis is helping the scientific community to identify novel targets for chemotherapeutic interventions and how this helped to identify and assess the potential of new identified targets is discussed.
Journal ArticleDOI
Evaluating the Accuracy of Molecular Diagnostic Testing for Canine Visceral Leishmaniasis Using Latent Class Analysis
Manuela da Silva Solcà,Leila Andrade Bastos,Carlos Eduardo Sampaio Guedes,Marcelo Bordoni,Lairton Souza Borja,Daniela Farias Larangeira,Daniela Farias Larangeira,Pétala Gardênia da Silva Estrela Tuy,Leila Denise Alves Ferreira Amorim,E. G. Nascimento,Geraldo G. S. Oliveira,Washington Luis Conrado dosSantos,Deborah Bittencourt Mothé Fraga,Deborah Bittencourt Mothé Fraga,Patrícia Sampaio Tavares Veras +14 more
TL;DR: Evaluating the accuracy of molecular diagnostic testing in dogs from an endemic area for canine visceral leishmaniasis (CVL) by determining which tissue type provided the highest rate of parasite DNA detection confirmed that the splenic aspirate is the most effective type of tissue for detecting L. infantum infection.
Journal ArticleDOI
Proteomic analysis reveals differentially expressed proteins in macrophages infected with Leishmania amazonensis or Leishmania major.
Juliana Perrone Bezerra de Menezes,Taís Fontoura de Almeida,Antonio Luis de Oliveira Almeida Petersen,Antonio Luis de Oliveira Almeida Petersen,Carlos Eduardo Sampaio Guedes,M. S. V. Mota,M. S. V. Mota,Jonilson Berlink Lima,Jonilson Berlink Lima,Luana Carneiro Palma,Luana Carneiro Palma,Gregory A. Buck,Marco Aurélio Krieger,Christian Probst,Patrícia Sampaio Tavares Veras +14 more
TL;DR: This study is the first to use a proteomics approach to describe the protein modulations involved in cellular metabolism during the initial events of Leishmania-macrophage interaction and hypothesize that these differentially expressed proteins likely play a pivotal role in determining the course of infection.
Journal ArticleDOI
Qualitative and quantitative polymerase chain reaction (PCR) for detection of Leishmania in spleen samples from naturally infected dogs.
Manuela da Silva Solcà,Carlos Eduardo Sampaio Guedes,E. G. Nascimento,Geraldo G. S. Oliveira,Washington Luis Conrado dos Santos,Deborah Bittencourt Mothé Fraga,Deborah Bittencourt Mothé Fraga,Patrícia Sampaio Tavares Veras +7 more
TL;DR: Standardized cPCR protocol is established as the most indicated test to detect Leishmania when compared to the other two diagnostic methods evaluated, and qPCR revealed the better performance analysis whenCompared to other diagnostic methods.
Journal ArticleDOI
17-AAG kills intracellular Leishmania amazonensis while reducing inflammatory responses in infected macrophages.
Antonio Luis de Oliveira Almeida Petersen,Antonio Luis de Oliveira Almeida Petersen,Carlos Eduardo Sampaio Guedes,Carolina Leite Versoza,José Geraldo Bomfim Lima,José Geraldo Bomfim Lima,Luiz Antonio Rodrigues de Freitas,Luiz Antonio Rodrigues de Freitas,Valéria M. Borges,Patrícia Sampaio Tavares Veras +9 more
TL;DR: The HSP90 inhibitor, 17-AAG, possesses high potency under low dosage and reduces both pro-inflammatory and oxidative molecule production and is warranted in the development of new generations of anti-leishmanials.