Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Pattern Recognition and Machine Learning

Man against machine: diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists.

Melanoma is the deadliest form of skin cancer. While curable with early detection, only highly trained specialists are capable of accurately recognizing the disease. As expertise is in limited supply, automated systems capable of identifying disease could save lives, reduce unnecessary biopsies, and reduce costs. Toward this goal, we propose a system that combines recent developments in deep learning with established machine learning approaches, creating ensembles of methods that are capable of segmenting skin lesions, as well as analyzing the detected area and surrounding tissue for melanoma detection. The system is evaluated using the largest publicly available benchmark dataset of dermoscopic images, containing 900 training and 379 testing images. New state-of-the-art performance levels are demonstrated, leading to an improvement in the area under receiver operating characteristic curve of 7.5% (0.843 versus 0.783), in average precision of 4% (0.649 versus 0.624), and in specificity measured at the clinically relevant 95% sensitivity operating point 2.9 times higher than the previous state of the art (36.8% specificity compared to 12.5%). Compared to the average of eight expert dermatologists on a subset of 100 test images, the proposed system produces a higher accuracy (76% versus 70.5%), and specificity (62% versus 59%) evaluated at an equivalent sensitivity (82%).

Deep learning ensembles for melanoma recognition in dermoscopy images

Automated skin lesion classification in dermoscopy images is an essential way to improve the diagnostic performance and reduce melanoma deaths. Although deep convolutional neural networks (DCNNs) have made dramatic breakthroughs in many image classification tasks, accurate classification of skin lesions remains challenging due to the insufficiency of training data, inter-class similarity, intra-class variation, and the lack of the ability to focus on semantically meaningful lesion parts. To address these issues, we propose an attention residual learning convolutional neural network (ARL-CNN) model for skin lesion classification in dermoscopy images, which is composed of multiple ARL blocks, a global average pooling layer, and a classification layer. Each ARL block jointly uses the residual learning and a novel attention learning mechanisms to improve its ability for discriminative representation. Instead of using extra learnable layers, the proposed attention learning mechanism aims to exploit the intrinsic self-attention ability of DCNNs, i.e., using the feature maps learned by a high layer to generate the attention map for a low layer. We evaluated our ARL-CNN model on the ISIC-skin 2017 dataset. Our results indicate that the proposed ARL-CNN model can adaptively focus on the discriminative parts of skin lesions, and thus achieve the state-of-the-art performance in skin lesion classification.

Attention Residual Learning for Skin Lesion Classification

Melanoma is one of the deadliest forms of cancer; hence, great effort has been put into the development of diagnosis methods for this disease. This paper addresses two different systems for the detection of melanomas in dermoscopy images. The first system uses global methods to classify skin lesions, whereas the second system uses local features and the bag-of-features classifier. This paper aims at determining the best system for skin lesion classification. The other objective is to compare the role of color and texture features in lesion classification and determine which set of features is more discriminative. It is concluded that color features outperform texture features when used alone and that both methods achieve very good results, i.e., Sensitivity = 96% and Specificity = 80% for global methods against Sensitivity = 100% and Specificity = 75% for local methods. The classification results were obtained on a data set of 176 dermoscopy images from Hospital Pedro Hispano, Matosinhos.

Two Systems for the Detection of Melanomas in Dermoscopy Images Using Texture and Color Features

Robustness is one of the most important characteristics of computer-aided diagnosis systems designed for dermoscopy images. However, it is difficult to ensure this characteristic if the systems operate with multisource images acquired under different setups. Changes in the illumination and acquisition devices alter the color of images and often reduce the performance of the systems. Thus, it is important to normalize the colors of dermoscopy images before training and testing any system. In this paper, we investigate four color constancy algorithms: Gray World, max-RGB, Shades of Gray, and General Gray World. Our results show that color constancy improves the classification of multisource images, increasing the sensitivity of a bag-of-features system from 71.0% to 79.7% and the specificity from 55.2% to 76% using only 1-D RGB histograms as features.

Improving Dermoscopy Image Classification Using Color Constancy

Dermoscopy image analysis (DIA) is a growing field, with works being published every week. This makes it difficult not only to keep track of all the contributions, but also for new researchers to identify relevant information and new directions to be explored. Several surveys have been written in the past decade, but these tend to cover all of the steps of a CAD system, which can be overwhelming. Moreover, in these works, each of the steps is briefly discussed due to lack of space. Among the different blocks of the CAD system, the most relevant is the one devoted to feature extraction. This is also the block where existing works exhibit the most variability. Therefore, we believe that it is important to review the state-of-the-art on this matter. This work thoroughly explores the several types of features that have been used in DIA. A discussion on their relevance and limitations, as well as suggestions for future research are provided.

A Survey of Feature Extraction in Dermoscopy Image Analysis of Skin Cancer

A pigment network is one of the most important dermoscopic structures. This paper describes an automatic system that performs its detection in dermoscopy images. The proposed system involves a set of sequential steps. First, a preprocessing algorithm is applied to the dermoscopy image. Then, a bank of directional filters and a connected component analysis are used in order to detect the “lines” of the pigment network. Finally, features are extracted from the detected network and used to train an AdaBoost algorithm to classify each lesion regarding the presence of the pigment network. The algorithm was tested on a dataset of 200 medically annotated images from the database of Hospital Pedro Hispano (Matosinhos), achieving a sensitivity = 91.1% and a specificity = 82.1%.

Catarina Barata

Papers

Two Systems for the Detection of Melanomas in Dermoscopy Images Using Texture and Color Features

Improving Dermoscopy Image Classification Using Color Constancy

A Survey of Feature Extraction in Dermoscopy Image Analysis of Skin Cancer

A System for the Detection of Pigment Network in Dermoscopy Images Using Directional Filters

Development of a clinically oriented system for melanoma diagnosis