Cécile Calléja

TL;DR: A Cre-dependent genetic switch (FLEx switch) is designed that can readily detect, in the mouse, at the single cell level, Cre-mediated gene ablation and is discussed how this strategy can be used to generate genetic modifications in a conditional manner.

TL;DR: It is demonstrated that the topical retinoid signal is transduced by RXRα/RARγ heterodimers in suprabasal keratinocytes, which, in turn, stimulate proliferation of basal keratinocyte proliferation via a paracrine signal that may be heparin‐binding EGF‐like growth factor.

TL;DR: It is demonstrated for the first time that subordination of RXR transcriptional activity to that of its RAR partner plays a crucial role in vivo, because it allows RXRs to act concomitantly, within the same cell, as heterodimerization partners for repression, as well as for activation events in which they are transcriptionally active.

TL;DR: This chapter focuses on the use of animal models to study nuclear receptor function and the ways conditional mutagenesis approach allows revealing the precise physiological role of nuclear receptors in a given adult tissue.

TL;DR: In this article, le role of RA in the physiologie de l'epiderme has been investigated, i.e. the role of the metabolite actif de la vitamine A (l'acide retinoique, RA) in the development of the human body.