C
Celia López-Sanz
Researcher at University of Valencia
Publications - 11
Citations - 476
Celia López-Sanz is an academic researcher from University of Valencia. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 6, co-authored 6 publications receiving 219 citations.
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Journal ArticleDOI
IL-6 serum levels predict severity and response to Tocilizumab in COVID-19: an observational study
José María Galván-Román,Sebastián C Rodríguez-García,Emilia Roy-Vallejo,Ana Marcos-Jimenez,Santiago Sánchez-Alonso,C. Fernández-Díaz,Ana Alcaraz-Serna,Tamara Mateu-Albero,Pablo Rodriguez-Cortes,Ildefonso Sánchez-Cerrillo,Laura Esparcia,Pedro Martínez-Fleta,Celia López-Sanz,Ligia Gabrie,Luciana del Campo Guerola,Carmen Suárez-Fernández,Julio Ancochea,Alfonso Canabal,Patricia Albert,Diego A Rodríguez-Serrano,Juan Mariano Aguilar,Carmen Del Arco,Ignacio Santos,Lucio García-Fraile,Rafael de la Cámara,José María Serra,Esther Limón Ramírez,Tamara Alonso,Pedro Landete,Joan B. Soriano,Enrique Martin-Gayo,Arturo Fraile Torres,Nelly D. Zurita Cruz,Rosario García-Vicuña,Laura Cardeñoso,Francisco Sánchez-Madrid,Arantzazu Alfranca,Cecilia Muñoz-Calleja,Isidoro González-Álvaro +38 more
TL;DR: Baseline IL-6 levels>30 pg/ml predicts IMV requirement in patients with COVID-19 and contributes to establish an adequate indication for TCZ administration.
Journal ArticleDOI
COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes.
Ildefonso Sánchez-Cerrillo,Pedro Landete,Beatriz Aldave,Santiago Sánchez-Alonso,Ana Sanchez-Azofra,Ana Marcos-Jimenez,Elena Ávalos,Ana Alcaraz-Serna,Ignacio Santos,Tamara Mateu-Albero,Laura Esparcia,Celia López-Sanz,Pedro Martínez-Fleta,Ligia Gabrie,Luciana del Campo Guerola,Hortensia de la Fuente,Maria J. Calzada,Isidoro González-Álvaro,Arantzazu Alfranca,Francisco Sánchez-Madrid,Cecilia Muñoz-Calleja,Joan B. Soriano,Julio Ancochea,Enrique Martín-Gayo +23 more
TL;DR: It is indicated that inflammatory transitional and non-classical monocytes and CD1c+ conventional dendritic cells preferentially migrate from blood to lungs in patients with severe COVID-19, which could be useful for the design of therapeutic strategies to fight SARS-CoV-2 infection.
Posted ContentDOI
Differential Redistribution of Activated Monocyte and Dendritic Cell Subsets to the Lung Associates with Severity of COVID-19
Ildefonso Sánchez-Cerrillo,Pedro Landete,Beatriz Aldave,Santiago Sánchez-Alonso,Ana Sanchez-Azofra,Ana Marcos-Jimenez,Elena Ávalos,Ana Alcaraz-Serna,Ignacio Santos,Tamara Mateu-Albero,Laura Esparcia,Celia López-Sanz,Pedro Martínez-Fleta,Ligia Gabrie,Luciana del Campo Guerola,Maria J. Calzada,Isidoro González-Álvaro,Arantzazu Alfranca,Francisco Sánchez-Madrid,Cecilia Muñoz-Calleja,Joan B. Soriano,Julio Ancochea,Enrique Martin-Gayo +22 more
TL;DR: It is suggested that inflammatory transitional and non-classical monocytes preferentially migrate from blood to lungs in patients with severe COVID-19, which could be useful for the design of therapeutic strategies to fight SARS-CoV-2 infection.
Journal ArticleDOI
SARS-CoV-2 Cysteine-like Protease Antibodies Can Be Detected in Serum and Saliva of COVID-19-Seropositive Individuals.
Pedro Martínez-Fleta,Arantzazu Alfranca,Isidoro González-Álvaro,José M. Casasnovas,Daniel Fernández-Soto,Gloria Esteso,Yaiza Cáceres-Martell,Sofia R. Gardeta,Celia López-Sanz,Salomé Prat,Tamara Mateu-Albero,Ligia Gabrie,Eduardo López-Granados,Francisco Sánchez-Madrid,Hugh T. Reyburn,José María Frade,Mar Valés-Gómez +16 more
TL;DR: Mpro is a potent Ag in infected patients that can be used in serological tests, and its detection in saliva could be the basis for a rapid, noninvasive test for COVID-19 seropositivity.
Journal ArticleDOI
Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID-19 patients.
Ana Marcos-Jimenez,Santiago Sánchez-Alonso,Ana Alcaraz-Serna,Laura Esparcia,Celia López-Sanz,Miguel Sampedro-Núñez,Tamara Mateu-Albero,Ildefonso Sánchez-Cerrillo,Pedro Martínez-Fleta,Ligia Gabrie,Luciana del Campo Guerola,José Miguel Rodríguez-Frade,José M. Casasnovas,Hugh T. Reyburn,Mar Valés-Gómez,Margarita López-Trascasa,Enrique Martin-Gayo,Maria J. Calzada,Santos Castañeda,Hortensia de la Fuente,Isidoro González-Álvaro,Francisco Sánchez-Madrid,Cecilia Muñoz-Calleja,Arantzazu Alfranca +23 more
TL;DR: This study provides important clues to understand the immune response observed in COVID‐19 patients, associating severity with an imbalanced humoral response, and identifying new targets for therapeutic intervention.