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Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
Publications - 1
Citations - 118
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas is an academic researcher. The author has contributed to research in topics: ASK1 & Cell signaling. The author has an hindex of 1, co-authored 1 publications receiving 101 citations.
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Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.
Mireia Niso-Santano,Rosa A. González-Polo,José Manuel Bravo-San Pedro,Rubén Gómez-Sánchez,Isabel Lastres-Becker,Miguel A. Ortiz-Ortiz,Germán Soler,Jose M. Moran,Antonio Cuadrado,José M. Fuentes,Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas +10 more
TL;DR: This study identifies ASK 1/JNK and ASK1/p38 as two critical pathways involved in the activation of cell death under oxidative stress conditions and identifies the Nrf2/Trx axis as a new target to block these pathways and protect from oxidant exposure such as that found in Parkinson and other neurodegenerative diseases.