Cesare Carani

TL;DR: The responses to androgen and estrogen in a man with a novel, homozygous inactivating mutation of cytochrome P-450 aromatase suggest a crucial role of estrogen in skeletal maturation.

TL;DR: This new case of aromatase deficiency confirms previous data on bone maturation and mineralization, and reveals a high risk for the precocious development of cardiovascular disease in young aromat enzyme-deficient men.

TL;DR: Most patients with thyroid hormone disorders experience some sexual dysfunctions, which can be reversed by normalizing thyroid hormone levels, and their prompt reversibility suggest a direct involvement of thyroid hormones in the physiology of ejaculation.

TL;DR: The estimated frequency of deletions involving the DAZ locus is 3% in azoospermic-severely oligozoospermic men consulting an infertility clinic, and polymerase chain reaction amplification of theDAZ loci is useful for the diagnosis of microdeletions of the Y chromosome.

TL;DR: The once-in-a-lifetime discovery of a new type of “silicon-like” substance that binds to the thyroid gland has implications for diagnosis and treatment of thyroid-related cancers.