Chandraiah Godugu

TL;DR: The significance of nanosizing on the pharmacological activity of Se has been discussed and the role of SeNPs in pharmacological protection against various inflammatory and oxidative stress mediated conditions is presented.

TL;DR: The cytotoxicity, spheroid size distribution, immunohistochemistry, RT-PCR and nanoparticle penetration data suggested that in vitro tumor models show higher resistance to anticancer drugs and supporting the fact that 3D culture is a better model for the cytotoxic evaluation of antic cancer drugs in vitro.

TL;DR: Tmx-NPs showed the marked reduction in hepatotoxicty when compared with free Tmx citrate as evidenced by histopathological examination of liver tissue as well as AST, ALT and MDA levels, and could have the significant value for the oral chronic breast cancer therapy with reduced hepatotoxicity.

TL;DR: Toxicity of MWCNTs systematically decreased with the increased functionalization density, and acid-oxidized carboxylated CNTs with shorter lengths, hydrophilic surfaces, and high aqueous dispersibility proved to be less toxic and more biocompatible than their pristine counterparts.

TL;DR: Synthetic routes have led to interesting analogues of coumarins which possess pharmacological activities like anti-HIV, antimicrobial, antiinflammatory, anticancer, anti-TB, anticonvulsant and MAO inhibitory properties.