C
Changhe Yu
Researcher at Nippon Medical School
Publications - 2
Citations - 25
Changhe Yu is an academic researcher from Nippon Medical School. The author has contributed to research in topics: Transforming growth factor & Lung cancer. The author has an hindex of 2, co-authored 2 publications receiving 24 citations.
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Journal ArticleDOI
Effects of gefitinib on radiation-induced lung injury in mice.
Chunyan Wang,Shinji Abe,Kuniko Matsuda,Changhe Yu,Ying-Ji Li,Jiro Usuki,Arata Azuma,Shoji Kudoh +7 more
TL;DR: The results suggest that gefitinib does not exacerbate radiation-induced lung injury and fibrosis in this strain of mice, and thoracic irradiation is unlikely to be a risk factor for lung injury associated with gefITinib treatment.
Journal ArticleDOI
EM703, A NEW DERIVATIVE OF ERYTHROMYCIN, INHIBITS TRANSFORMING GRWTH FACTOR-β SIGNALING IN HUMAN LUNG FIBROBLASTS
Changhe Yu,Arata Azuma,Ying-Ji Li,Chunyan Wang,Sinji Abe,Jiro Usuki,Kuniko Matsuda,Shoji Kudoh,Toshiaki Sunazuka,Satoshi Omura +9 more
TL;DR: EM-A and EM703 inhibit TGF-β signaling in human lung fibroblasts via inhibition of p-Smad2/3 through recovery of Smad7 level, suggesting that the mechanisms of the anti-inflammatory effects of macrolides remain unknown.