Chantelle L. White

TL;DR: The current state of knowledge regarding the mechanisms of protection elicited by LAIV in children are discussed, this with immune protection that develops upon vaccination with inactivated influenza vaccines is compared, and both the potential advantages as well as challenges offered by this vaccination platform are discussed.

TL;DR: It is found that the influenza protein-specific immunodominance pattern in children differs from that in young adults, with much lower reactivity to the NP internal virion protein in young children.

TL;DR: Using a peptide-based priming strategy, it is found that selective expansion of the anti-HA CD4 T cell memory repertoire enhanced HA-specific antibody production upon heterosubtypic infection and could be a potentially useful pre-pandemic vaccination strategy to promote accelerated neutralizing antibody production on challenge with a pandemic influenza strain that contains few conserved HA epitopes.

TL;DR: In this article, the authors evaluated circulating human CD4 T cells collected prior to 2020 for reactivity towards hCoV spike proteins, probing for the ability to produce interferon-γ, interleukin-2, or granzyme B.

TL;DR: It is indicated that infection and vaccination differentially prime influenza-specific CD4 T cell responses in early childhood, with these differences contributing to the lasting immunologic imprinting established following early influenza infection.