C
Chao He
Researcher at Sir Run Run Shaw Hospital
Publications - 26
Citations - 1429
Chao He is an academic researcher from Sir Run Run Shaw Hospital. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 13, co-authored 26 publications receiving 1193 citations.
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Journal ArticleDOI
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment
Xinbing Sui,R Chen,Z Wang,Z Huang,Na Kong,M Zhang,Weidong Han,Fang Lou,Jing Yang,Qian Zhang,Xian Wang,Chao He,Hongming Pan +12 more
TL;DR: Understanding the novel function of autophagy may allow us to develop a promising therapeutic strategy to enhance the effects of chemotherapy and improve clinical outcomes in the treatment of cancer patients.
Journal ArticleDOI
Knockdown of the novel proteasome subunit Adrm1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity.
TL;DR: The novel proteasome subunit Adrm1 located on the 20q13 amplicon was differentially expressed in colorectal cancer by semiquantitative RT-PCR and stable RNA interference of AdRM1 gene synergistic with 5-Fu treatment suppressed RKO cell growth in vitro, suggesting that Adrm 1 is potentially oncogenic and may play an important role in colon tumorigenesis.
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Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation.
Xinbing Sui,Yinghua Xu,Jie Yang,Yong Fang,Haizhou Lou,Weidong Han,Maolin Zhang,Wei Chen,Kaifeng Wang,Da Li,Wei Jin,Fang Lou,Yu Zheng,Hong Hu,Liu Gong,Xiaoyun Zhou,Qin Pan,Hongming Pan,Xian Wang,Chao He +19 more
TL;DR: It is suggested that metformin has not antineoplastic activity for CRC cells as a single agent but AMPK activator AICAR can induce apoptosis and enhance the cytotoxic effect of 5-FU through AMPK activation.
Journal Article
TGFBI protein high expression predicts poor prognosis in colorectal cancer patients.
TL;DR: TGFBI plays an important role in the progression of colorectal cancers and it is an independent poor prognostic factor for coloreCTal cancer patients, which is significantly lower in patients with high TGFBI expression.
Journal ArticleDOI
The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer.
TL;DR: The results indicated that PSMA7 may play an important role in colorectal cancer progression and provide a unique target site for the development of therapeutic drugs.