Fang Lou

TL;DR: Understanding the novel function of autophagy may allow us to develop a promising therapeutic strategy to enhance the effects of chemotherapy and improve clinical outcomes in the treatment of cancer patients.

TL;DR: The results suggest that JNK activation confers 5-FU resistance in HCT116 p53−/− and HT29 cells by promoting autophagy as a pro-survival effect, likely via inducing Bcl-2 phosphorylation.

TL;DR: The role of autophagy in immune regulation is described, the possible molecular mechanisms that are currently well documented in the ability of autophileagy to control cell immune response are summarized, and the scientific and clinical hurdles regarding the potential role of Autophileagy in cancer immunotherapy are discussed.

TL;DR: The early diagnosis of rare MPMTs should not be neglected in patients not only when treated for a primary malignancy but also during long-term follow-up, and effective treatment for MP MTs may yield promising curative effect and warrants further investigation.

TL;DR: It is suggested that metformin has not antineoplastic activity for CRC cells as a single agent but AMPK activator AICAR can induce apoptosis and enhance the cytotoxic effect of 5-FU through AMPK activation.