This paper reviews the literature on analytical applications of flow injection (FI) techniques with chemiluminescence (CL) detection from 1995-1999. The focus is on the application of FI-CL to the quantitative determination of specific analytes in real sample matrices. Therefore, entries have been tabulated under the most appropriate application area, ie pharmaceutical, environmental, foods and beverages and biomedical, as defined by the matrix that has been analysed. Each table lists analytes alphabetically and gives details of the exact sample matrix, the limit of detection (as reported in the original paper) and comments on the CL reaction used.

Analytical applications of flow injection with chemiluminescence detection--a review.

A review on applications of chemiluminescence detection in food analysis.

Nonlinear matrix equations arise in different scientific topics, such as applied statistics and control theory, among others. Standard approaches to solve them include and combine some variations of Newton’s method, matrix factorizations, and reduction to generalized eigenvalue problems. In this paper we explore the use of secant methods in the space of matrices, that represent a new approach with interesting features. For the special problem of computing the inverse or the pseudoinverse of a given matrix, we propose a specialized secant method for which we establish stability and q-superlinear convergence, and for which we also present some numerical results. In addition, for solving quadratic matrix equations, we discuss several issues, and present preliminary and encouraging numerical experiments.

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Universidad central de venezuela

Recent developments and applications of chemiluminescence sensors

The levulinate ester of 2-(benzothiazol-2-yl)phenol, 1, has been developed as a ratiometric fluorescent probe for identifying and quantitating sulfite anions. The mechanism of action is based on the sulfite-triggered intramolecular cleavage of the levulinate moiety to give 1 which, when excited with 310 nm light, decays to its ground state via an excited state intramolecular proton transfer (ESIPT) mediated pathway. We show that the intensity of the ESIPT fluorescent signal relative to that of 1 is proportional to sulfite concentration. This new probe shows good selectivity and high sensitivity for sulfite over other typically encountered anions (F−, Cl−, Br−, I−, HPO42−, SO42−, NO3−, AcO−, ClO4−, N3−, HCO3−) when measured in CH3CN/H2O (50 : 50, v/v) solution.

A highly sulfite-selective ratiometric fluorescent probe based on ESIPT

Chemiluminescence of sulfite based on auto-oxidation sensitized by rhodamine 6G

Chemiluminescence analysis of menadione sodium bisulfite and analgin in pharmaceutical preparations and biological fluids.

A flow-injection chemiluminescence (CL) analysis for the determination of analgin is presented. It is based on the CL reaction of analgin with Ce (IV) in sulphuric acid sensitized by the fluorescent dye Rhodamine 6G. The proposed procedure has a linear range of 0.05-10ug/ml, with a relative standard deviation (RSD) of 2.1% at 1.0ug/ml. The detection limit (3σ) is 0.02ug/ml. The method has been successfully applied to the determination of analgin in tablets.

Cerium (IV)-Based Chemiluminescence Analysis of Analgin

A novel chemiluminescence (CL) flow-through sensor for the determination of analgin with flow-injection analysis (FIA) based on the auto-oxidation of analgin in the presence of Tween 80 sensitized by Rhodamine 6G immobilized on a cation-exchange column is described. This sensor responds linearly to the analgin concentration in the range of 0.4 ∼ 10 mg/L, with a detection limit (3σ) of 0.15 mg/L. A complete analysis, including sampling and washing, takes 1 min with a relative standard deviation of < 5%. The sensor is stable for over 200 determinations and has successfully been applied to the determination of analgin in pharmaceutical preparations.

A novel chemiluminescence flow-through sensor for the determination of analgin

A chemiluminescence biosensor combined with flow injection analysis has been developed for determining cholesterol. Cholesterol oxidase was immobilized onto amine-modified silica gel via glutaraldehyde activation and packed in a column. The analytical reagents, including luminol and ferricyanide, were electrostatically coimmobilized on an anion-exchange column. Cholesterol was sensed by the CL reaction between hydrogen peroxide released from the enzymatic reaction and luminol and ferricyanide, which were released from a column with immobilized reagents by elution. The calibration graph was linear over the range 5×10-6 to 1×10-4 g ml-1 and the detection limit was 5×10-6 g ml-1. The pro-posed method has been successfully applied to the determination of cholesterol in human serum.

Chao Zhang

Papers

Chemiluminescence of sulfite based on auto-oxidation sensitized by rhodamine 6G

Chemiluminescence analysis of menadione sodium bisulfite and analgin in pharmaceutical preparations and biological fluids.

Cerium (IV)-Based Chemiluminescence Analysis of Analgin

A novel chemiluminescence flow-through sensor for the determination of analgin

Chemiluminescence Flow Biosensor System for Cholesterol with Immobilized Reagents