Charles D. Cox

TL;DR: Increased release of IL-8, a potent neutrophil chemoattractant, in response to pyocyanin could contribute to the marked infiltration of neutrophils and subsequent neutrophIL-mediated tissue damage that are observed in Pseudomonas-associated lung disease.

TL;DR: In this article, the authors used spin trap evidence of hydroxyl radical formation was detected when NADH and pyocyanin were allowed to react in the presence of ferripyochelin.

TL;DR: The data presented in this study not only furnish some additional insights into the structure–function relationships of Fur, but also afford novel perspectives with regard to Fur and the iron‐dependent regulation of virulence factors in P. aeruginosa under environmental conditions that have not previously been considered.

TL;DR: Two copper-binding compounds/cofactors were isolated from the spent media of both the wild type and a constitutive soluble methane monooxygenase mutant, PP319, and high concentrations of CBCs were observed in the extracellular fraction of the sMMOC mutants PP319 and PP359 regardless of the copper concentration in the culture medium.

TL;DR: The pyocyanine-dependent [Ca2+]cincrease appears to be oxidant dependent and to result from increased inositol trisphosphate and release of Ca2+ from intracellular stores.