Active programmable electronic devices for molecular biological analysis and diagnostics

Disclosed are a liquid crystal display device which reduces the number of masks and improves an aperture ratio, and a method for fabricating the same. The liquid crystal display device includes gate and data lines perpendicularly intersecting on a substrate having pixel and pad parts; a thin film transistor on the substrate at the intersection of the gate and data lines; a pixel electrode on the substrate at the pixel part and connected directly to a drain electrode of the thin film transistor; an insulating film on the overall surface of the substrate including the pixel electrode and the thin film transistor; an organic film on the insulating film over the thin film transistor and the data line; and a common electrode of slit shapes overlapping the pixel electrode such that the insulating film is interposed between the common electrode and the pixel electrode.

Liquid crystal display device and method for fabricating the same

A system for performing molecular biological diagnosis, analysis and multi-step and multiplex reactions utilizes a self-addressable, self-assembling microelectronic system for actively carrying out controlled reactions in microscopic formats. These reactions include most molecular biological procedures, such as nucleic acid hybridization, antibody/antigen reaction, and clinical diagnostics. Multi-step combinatorial biopolymer synthesis may be performed. A controller interfaces with a user via input/output devices, preferably including a graphical display. Independent electronic control is achieved for the individual microlocations. In the preferred embodiment, the controller interfaces with a power supply and interface, the interface providing selective connection to the microlocations, polarity reversal, and optionally selective potential or current levels to individual electrodes. A system for performing sample preparation, hybridization and detection and data analysis integrates multiple steps within a combined system. Charged materials are transported preferably via free field electrophoresis. DNA complexity reduction is achieved preferably by binding of DNA to a support, followed by cleaving unbound materials, such as by restriction enzymes, followed by transport of the cleaved DNA fragments. Active, programmable matrix devices are formed in a variety of formats, including a square matrix pattern with fanned out electrical connections, an array having electrical connections and optionally optical connections from beneath the specific microlocations. A highly automated DNA diagnostic system results.

Molecular biological diagnostic systems including electrodes

A unique method/system for simultaneously creating and transferring a contrasting pattern of intelligence on and from a composite ablation-transfer imaging medium to a receptor element in contiguous registration therewith is improvedly radiation sensitive and versatile, is kinetically rapid and not dependent on a sensitized ablative topcoat, and is well adopted for such applications as, e.g., color proofing and printing, the security coding of various documents and the production of masks for the graphic arts and printed circuit industries; the composite ablation-transfer imaging medium, per se, comprises a support substrate (i), at least one intermediate "dynamic release layer" (ii) essentially coextensive therewith and an imaging radiation-ablative carrier topcoat (iii) also essentially coextensive therewith, said imaging radiation-ablative carrier topcoat (iii) including an imaging amount of a contrast imaging material contained therein, and said at least one dynamic release layer (ii) absorbing such imaging radiation at a rate sufficient to effect the imagewise ablation mass transfer of at least said carrier topcoat (iii).

Ablation-transfer imaging/recording

Laminates (600) having microfluidic structures (615-635) disposed between sheets (605-610) of the laminate (600) are provided. The microfluidic structures (615-635) are raised on a sheet (605, 610) of the laminate (600), typically by printing the structure (615-635) on the sheet (605, 610). Printing methods include Serigraph, ink-jet, intaligo, offset printing and thermal laser printing.

Fabrication of microfluidic circuits by "printing" techniques

Infrared absorbing cyanine dyes for dye-donor element used in laser-induced thermal dye transfer

A lithographic printing plate that has an imaging layer that comprises an admixture of (1) a resole resin, (2) a novolac resin, (3) a latent Bronsted acid and (4) an infrared absorber; that is sensitive to both ultraviolet and infrared radiation; and that is capable of functioning in either a positive-working or negative-working manner is imagewise exposed with a laser diode that emits a high-intensity infrared laser beam which provides enhanced image sharpness.

Method of imaging a lithographic printing plate

An imaging system having a source of light movable with respect to a writing element and projectable thereon to generate an image. A focusing system is provided for focusing a light source which generates a first beam of light of a wavelength selected to be actinic with respect to the writing element. At least a portion of the first beam of light is absorbed by the writing element, The apparatus includes a material supply to automatically supply donor sheets and receiver sheets independently to a writing platen or drum, and to selectively load and unload the donor sheets from superposition with the receiver sheet without disturbing the registration of the receiver sheet.

Laser thermal printer with an automatic material supply

-i-INFRARED ABSORBING SQUARYLIUMDYES FOR DYE-DONOR ELEMENT USEDIN LASER-INDUCED THERMAL DYE TRANSFER Abstract A dye-donor element for laser-induced thermal dye transfer comprising a support having thereon a dye layer and an infrared-absorbing material which is different from the dye in the dye layer, and wherein the infrared-absorbing material is a squarylium dye which is located in the dye layer.In a preferred embodiment, the squarylium dye has the following formula: wherein: R1, R2, R3 and R4 each independently represents hydrogen, hydroxy, halogen, cyano, alkoxy, aryloxy, acyloxy, aryloxycarbonyl, alkoxycarbonyl, sulfonyl, carbamoyl, acyl, acylamido, alkylamino, arylamino or a substituted or unsubstituted alkyl, aryl or hetaryl group;or any of said R1, R2, R3 or R4 groups may be combined with R5, R6, R7 or R8 or with each other to form a 5- to 7-membered substituted or unsubstituted carbocyclic or heterocyclic ring; -ii-R5, R6, R7 and R8 each independently represents hydrogen, a substituted or unsubstituted alkyl or cycloalkyl group having from 1 to about 6 carbon atoms or an aryl or hetaryl group having from about 5 to about 10 atoms;or R5 and R6 or R7 and R8 may be joined together to form a 5- to 7-membered substituted or unsubstituted nitrogen-containing heterocyclic ring; and n and m are each independently 1 to 4.

Infrared absorbing squarylium dyes for dye-donor element used in laser-induced thermal dye transfer

-i-INFRARED ABSORBING BIS(CHALCOGENOPYRYLO)POLYMETHINE DYES FOR DYE-DONOR ELEMENT USED IN LASER-INDUCED THERMAL DYE TRANSFER Abstract A dye-donor element for laser-induced thermal dye transfer comprising a support having thereon a dye layer and an infrared-absorbing material which is different from the dye in the dye layer, and wherein the infrared-absorbing material is a bis(chalcogenopyrylo)polymethine dye which is located in the dye layer. In a preferred embodiment, the bis(chalcogenopyrylo)polymethine dye has the following formula: wherein: R1, R2 and R3 each independently represents hydrogen, halogen, cyano, alkoxy, aryloxy, acyloxy, aryloxycarbonyl, alkoxycarbonyl, sulfonyl, carbamoyl, acyl, acylamido, alkylamino, arylamino or a substituted or unsubstituted alkyl, aryl or hetaryl group; or any two of said R1, R2 and R3 groups may be joined together to form a 5- to 7-membered substituted or unsubstituted carbcyclic or heterocyclic ring; or R1 may be joined to Z1 to form a fused S- to 7-membered substituted or unsubstituted carbocyclic or heterocyclic ring; or R3 may be joined to Z2 to form a fused 5- to 7-membered substituted or unsubstituted carbocyclic or heterocyclic ring; -ii-Y1 and Y2 each independently represents sulfur, oxygen, tellurium, or selenium, with the methine chain being joined ortho or para to each of y1 and Y2: Z1 and Z2 each independently represents hydrogen; a substituted or unsubstituted alkyl group having from 1 to about 6 carbon atoms; a substituted or unsubstituted aryl or hetaryl group having from about 5 to about 10 atoms; or the atoms necessary to complete a 5- to 7-membered carbocyclic or heterocyclic ring: each m independently is 1 to 4; n is 1 to 3; and X is a monovalent anion.

Charles D. DeBoer

Papers

Infrared absorbing cyanine dyes for dye-donor element used in laser-induced thermal dye transfer

Method of imaging a lithographic printing plate

Laser thermal printer with an automatic material supply

Infrared absorbing squarylium dyes for dye-donor element used in laser-induced thermal dye transfer

Infrared absorbing bis(chalcogenopyrylo)polymethine dyes for dye-donor element used in laser-induced thermal dye transfer