Charles F. Landry

TL;DR: Investigation of mammalian animal models of adolescence—such as those examining impulsivity, reward sensitivity, and decision making—may also provide new opportunities for addressing the problem of adolescent vulnerability.

TL;DR: Recent studies suggest that the central nervous system stores and utilizes information about 'natural' and drug reinforcers in similar ways, both neuroanatomically and biochemically, which may have important implications for the pharmacological and cognitive-behavioral treatments of substance use disorders, addiction, eating disorders, and obesity.

TL;DR: Orexin/hypocretin‐containing neurons in lateral sectors of the hypothalamus, along with cells in the arcuate nucleus, display phasic increases in Fos expression after an orexigenic pharmacological manipulation of the nucleus accumbens shell, but to a lesser degree after the heightened arousal associated with exposure to a novel environment.

TL;DR: It is suggested that mammalian GLD2 poly(A) polymerases are important in synaptic translation, and in polyadenylation throughout the soma, and for early animal development and synaptic plasticity.

TL;DR: It is suggested that in adolescence, the activity of specific early response genes is higher in brain regions critical for emotional regulation and decision-making, and nicotine affects key plasticity molecules in these areas in a manner different from the adult.