介绍了Kirk—Othmer Encyclopedia of Chemical Technology（化工技术百科全书）（第五版）电子图书网络版数据库，并对该数据库使用方法和检索途径作出了说明，且结合实例简单地介绍了该数据库的检索方法。

Kirk-Othmer Encyclopedia of Chemical Technology数据库介绍及实例

Photothermally triggered nitric oxide nanogenerator targeting type IV pili for precise therapy of bacterial infections

Synthesis of novel spiro[benzo[4,5]thiazolo[3,2-a]chromeno[2,3-d]pyrimidine-14,3′-indoline]-1,2′,13(2H)-triones via three component reaction

A green, convenient, and efficient one-pot synthesis of a new class of spiro[indolinepyranopyrimidine] derivatives was achieved in good yields by the multi-component reaction of N-alkyl-1-(methylthio)-2-nitroethenamine derived from the addition of various amines to nitroketene dithioacetal with isatin and barbituric acid derivatives in water at reflux conditions. Notably, the present method offers desirable advantages including good yields, use of water as green solvent, absence of catalyst, simple workup procedure, and easy purification process with no chromatographic technique.

A simple and environmentally benign synthesis of novel spiro[indoline-3,5′-pyrano[2,3-d]pyrimidine] derivatives in water

In this present work, the theoretical study of the synthesis of methyl 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl) benzoate and ethyl 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl) benzoate, using the Gaussian 09 based on the hybrid density functional theory method (DFT/B3LYP/6-311G (d, p)) was done. From the obtained results, an economical method for the synthesis of these compounds with a high yield was elaborated. This method involved two steps: the first one was the preparation of the 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl) benzoic acid by a reaction of an open-form fluorescein in a 1.0 M sodium hydroxide solution; and the second one was the formation of the corresponding esters using anhydrous methanol and ethanol. Those esters were characterized by conventional spectroscopic techniques, such as nuclear magnetic resonance, infrared, and mass spectroscopies. The theoretical results are in good correlation with those obtained experimentally. The analysis of the absorption spectra revealed that the synthesized compounds are colored pigments. The experimental study of the inhibition effect of those compounds on the corrosion of mild steel in a 1 M HCl solution performed using absorbance difference measurements demonstrated that the synthesized products are good inhibitors in an acidic environment at a concentration of 1.0 × 10–4 M. The surface analysis via the scanning electron microscope/dispersive X-ray technique showed that those compounds protect mild steel against corrosion by being adsorbed on its surface.

An Intelligent and Efficient Synthesis of New Inhibitors against Corrosion of Mild Steel in Acidic Media

A simple and efficient method for the synthesis of spiro[indoline-3,9'-xanthene]trione derivatives by means of condensation between isatins and 1,3-cyclohexanedione in the presence of a catalytic amount of magnesium perchlorate at 80 °C in 50% aqueous ethanol medium has been described. Notably, the present method offers desirable advantages of good yields, simplicity of workup procedure, easy purification, and reduced reaction times.

An Efficient Synthesis of Spiro[indoline-3,9'-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate.

The invention relates to a spiro-compound and a preparation method and application thereof, and belongs to the technical field of steroidal compounds. The spiro-compounds I and a hydrate thereof is used as an active ingredient, and compounded with a prodrug and a pharmaceutically acceptable salt or pharmaceutically acceptable carrier to form a pharmaceutical composition. The spiro-compound is applied to the fields of anti-tumor and the like, has strong capability of inhibiting cancer cells, and provides lead compound for developing new antitumor drugs.

Spiro-compound and preparation method and application thereof

The invention relates to an androstenedione derivative and a preparation method and application thereof, and belongs to the technical field of steroids. A compound I and a hydrate thereof are taken as active ingredients and matched with a prodrug, a pharmacologically acceptable salt or a pharmacologically acceptable carrier to form a pharmaceutical composition. The androstenedione derivative is applied to metastatic breast cancer and advanced breast cancer of postmenopausal women, and has relatively high medicinal value.

Chen Chunfeng

Papers

An Efficient Synthesis of Spiro[indoline-3,9'-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate.

Spiro-compound and preparation method and application thereof

Androstenedione derivative and preparation method and application thereof