C
Chen Yc
Researcher at National Taiwan University
Publications - 2
Citations - 207
Chen Yc is an academic researcher from National Taiwan University. The author has contributed to research in topics: Mutation (genetic algorithm) & Gene mutation. The author has an hindex of 2, co-authored 2 publications receiving 178 citations.
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Journal ArticleDOI
TP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolution
Hsin-An Hou,Wen-Chien Chou,Yuan-Yeh Kuo,Liu Cy,Liang-In Lin,Mei-Hsuan Tseng,Chiang Yc,Ming-Chih Liu,Chia-Wen Liu,Jih-Luh Tang,Ming Yao,Chi-Cheng Li,Shang-Yi Huang,Bor-Sheng Ko,Szu-Chun Hsu,Chien-Yuan Chen,Chien-Ting Lin,Shang-Ju Wu,Woei Tsay,Chen Yc,Hwei-Fang Tien +20 more
TL;DR: TP53 mutations are associated with distinct clinic-biological features and poor prognosis in de novo AML patients and are rather stable during disease progression, whereas the mutation was acquired only in 1 of the 126 TP53 wild-type patients when therapy-related AML originated from different clone emerged.
Journal ArticleDOI
Dynamics of ASXL1 mutation and other associated genetic alterations during disease progression in patients with primary myelodysplastic syndrome
Chen Tc,Hsin-An Hou,Chou Wc,Jih-Luh Tang,Yuan-Yeh Kuo,Chien-Yuan Chen,Mei-Hsuan Tseng,Huang Cf,Lai Yj,Chiang Yc,Lee Fy,Ming-Chih Liu,Chia-Wen Liu,Liu Cy,Ming Yao,Shang-Yi Huang,Bor-Sheng Ko,Szu-Chun Hsu,Shang-Ju Wu,Woei Tsay,Chen Yc,Hwei-Fang Tien +21 more
TL;DR: ASXL1 mutations in association with other genetic alterations may have a role in the development of myelodysplastic syndrome but contribute little to disease progression.