The invention belongs to the field of the traditional Chinese medicine and discloses a gynostemma pentaphylla flavonoid compound, a preparation and an application thereof in an antitumor drug. The method comprises the following steps: (1) extracting the rough gynostemma pentaphylla powder by adopting an alcohol solution for heating and refluxing, centrifuging and concentrating, thereby acquiring gynostemma pentaphylla ethyl alcohol extract; (2) using water for dissolving the extract, filtering, adopting petroleum ether for extracting the filtrate and adopting ethyl acetate for extracting lower-layer water phase; (3) performing vacuum concentration on the ethyl acetate phase, drying and adopting a chloroform-methyl alcohol mixed solvent for isocratic elution in a silica gel column, therebyacquiring multiple fractions; (4) pouring the fractions onto a gel column, eluting with methyl alcohol and collecting the fractions with equal analogous values; (5) pouring the fractions onto a ODS column, using methyl alcohol-water for isocratic elution, collecting the fractions and drying, thereby acquiring the gynostemma pentaphylla flavonoid compound. The gynostemma pentaphylla flavonoid compound prepared according to the invention has the advantages of high anti-tumor activity, low dosage and no toxic or side effect to normal human hepatic cells in same dosage.

Chen Ying Jie

Papers

The compound extracted from chin-shin oolong tea, and the use as an oral ghrelin receptor agonist thereof

Use of compound extracted from raw polygonum multiflorum thunb. as ghrelin receptor agonist