Methods and compositions are disclosed for an intra-articular injection for the treatment of osteoarthritis. The methods and compositions comprising combinations of hyaluronic acid and a bone morphogenetic protein, like rhGDF-5, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.

Compositions and methods for treating joints

A hyaluronic acid compound which is a reaction product between hyaluronic acid and a phosphatidyl ethanolamine. This compound has biocompatibility and bio-safety, and can be formed into a hydrogel or molded form having a certain shape. Making use of these properties, it is used to treat a knee joint, prevent the accretion of a tissue after an operation and keep a skin wet.

Hyaluronic Acid Compound, Hydrogel Thereof and Joint Treating Material

PROBLEM TO BE SOLVED: To obtain a base material for culturing cartilage exhibiting excellent promoting effects on histogenesis of a cartilage and an agent for repairing cartilage forming a cartilage capable of being transplanted to a living body SOLUTION: The base material for culturing cartilage is obtained by combining a lipid-bonded glycosaminoglycan to a biologically absorbable porous material

Base material for culturing cartilage and agent for repairing cartilage

It is intended to provide a hyaluronic acid compound which is a product of a reaction between hyaluronic acid and phosphatidylethanolamine. This compound is excellent in biocompatibility and biological safety and can be processed into a hydrogel or a molded article having a definite shape. By taking advantage of these properties, it is usable in treating knee joint or preventing postoperative tissue adhesion or as a skin moisturizing agent, etc.

Hyaluronic acid compound, hydrogel thereof and material for treating joint

The present invention provides an agent which induces acceleration of hard tissue formation, acceleration of cell differentiation and increase in cellular alkaline phosphatase activity, by directly acting on the cell. Specifically, it provides a hard tissue formation promoter, a cell differentiation inducer and a cellular alkaline phosphatase activity reinforcing agent comprising, as an active ingredient, a glycosaminoglycan or a salt thereof that keeps sulfate group and has the characteristics of the following (1) and (2): (1) a basic structure is a disaccharide repeating structure consisting of a hexuronic acid residue and a glucosamine residue, (2) one or less of the position among a 2-position hydroxyl group of a hexuronic acid residue, a 6-position hydroxyl group of a glucosamine residue and a 2-position amino group of the glucosamine residue in the basic structure of the aforementioned (1) does not have the sulfate group. In this connection, it is preferable that the hexuronic acid residue is a glucuronic acid residue or an iduronic acid residue.

Promoter for hard tissue formation

PROBLEM TO BE SOLVED: To obtain a bone induction promoter which can effectively promote bone induction even when it is administered in a small dosage or in a low concentration by using as the active ingredient a lipidbonded glycosaminoglycan composed of a glycosaminoglycan and a lipid bonded thereto or a pharmacologically acceptable salt thereof. SOLUTION: This promoter is desirably selected from among a bone induction promoter in which the glycosaminoglycan is hyaluronic acid, chondroitin, chondroitin sulfate, chondroitin polysulfate, dermatan sulfate, heparin, keratan sulfate, or keratan polysulfate, a bond induction promoter in which the lipid is a glycerolipid, a bone induction promoter in which the glycerolipid is a phospholipid, a bone induction promoter in which the phospholipid is phosphatidylethanolamine, a bone induction promoter in which the glycosaminoglycan is hyaluronic acid and the lipid is phosphatidylethanolamine, and a bone induction promoter in which the lipid is covalently bonded to the reducing terminal of the glycosaminoglycan.

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Papers

Bone induction promoter

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Papers

Bone induction promoter

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