C
Cheng-Ren Lin
Researcher at Peking Union Medical College
Publications - 30
Citations - 596
Cheng-Ren Lin is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Blood stasis & Reperfusion injury. The author has an hindex of 10, co-authored 30 publications receiving 473 citations.
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Journal ArticleDOI
Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway
Xiaodi Fan,Xiaodi Fan,Jun Wang,Jincai Hou,Cheng-Ren Lin,Alan Bensoussan,Dennis Hsu-Tung Chang,Jian-Xun Liu,Bing Wang +8 more
TL;DR: Berberine dose- and time-dependently reduced ox-LDL–induced inflammation and increased the ratio of LC3II/LC3I, and SQSTM1/p62 in J774A.1 cells.
Journal ArticleDOI
The Cardioprotective Effects of Citric Acid and L-Malic Acid on Myocardial Ischemia/Reperfusion Injury
Xi-Lan Tang,Jian-Xun Liu,Wei Dong,Peng Li,Lei Li,Cheng-Ren Lin,Yongqiu Zheng,Jincai Hou,Dan Li +8 more
TL;DR: It is suggested that both citric acid and L-malic acid have protective effects on myocardial ischemia/reperfusion injury; the underlying mechanism may be related to their anti-inflammatory, antiplatelet aggregation and direct cardiomyocyte protective effects.
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Protective Effect of Kaempferol on LPS plus ATP-Induced Inflammatory Response in Cardiac Fibroblasts
Xi-Lan Tang,Jian-Xun Liu,Wei Dong,Peng Li,Lei Li,Jincai Hou,Yongqiu Zheng,Cheng-Ren Lin,Jun-Guo Ren +8 more
TL;DR: Results showed that kaempferol at concentrations of 12.5 and 25 μg/mL significantly suppressed the release of TNF-α, IL-1β,IL-6, and IL-18 and inhibited activation of NF-κB and Akt in LPS plus ATP-induced cardiac fibroblasts.
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Ginkgo biloba Extract Inhibits Astrocytic Lipocalin-2 Expression and Alleviates Neuroinflammatory Injury via the JAK2/STAT3 Pathway After Ischemic Brain Stroke.
Yehao Zhang,Jian-Xun Liu,Jian-Xun Liu,Bin Yang,Yongqiu Zheng,Mingjiang Yao,Mingqian Sun,Li Xu,Cheng-Ren Lin,Dennis Hsu-Tung Chang,Fangze Tian +10 more
TL;DR: EGB is demonstrated to mediate neuro inflammation, which protects against ischemic brain injury by inhibiting astrogliosis and suppresses neuroinflammation via the LCN2-JAK2/STAT3 pathway, providing insight into a promising therapeutic strategy for ischeMIC stroke.
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MicroRNA-384-5p regulates ischemia-induced cardioprotection by targeting phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (PI3K p110δ)
TL;DR: Results show that miR-384-5p, an important protecting factor, plays a significant role in cardioprotection by regulating PIK3CD in myocardial ischemia.