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Chiara Zuccato
Researcher at University of Milan
Publications - 66
Citations - 9420
Chiara Zuccato is an academic researcher from University of Milan. The author has contributed to research in topics: Huntingtin & Huntington's disease. The author has an hindex of 35, co-authored 62 publications receiving 8691 citations. Previous affiliations of Chiara Zuccato include University of California, Irvine.
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Journal ArticleDOI
Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease
Chiara Zuccato,Andrea Ciammola,Dorotea Rigamonti,Blair R. Leavitt,Donato Goffredo,Luciano Conti,Marcy E. MacDonald,Robert M. Friedlander,Vincenzo Silani,Michael R. Hayden,Tõnis Timmusk,Simonetta Sipione,Elena Cattaneo +12 more
TL;DR: It is demonstrated that wild-type huntingtin up-regulates transcription of brain-derived neurotrophic factor (BDNF), a pro-survival factor produced by cortical neurons that is necessary for survival of striatal neurons in the brain.
Journal ArticleDOI
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
Chiara Zuccato,Marzia Tartari,Andrea Crotti,Donato Goffredo,Marta Valenza,Luciano Conti,Tiziana Cataudella,Blair R. Leavitt,Michael R. Hayden,Tõnis Timmusk,Tõnis Timmusk,Dorotea Rigamonti,Elena Cattaneo +12 more
TL;DR: It is concluded that wild-type huntingtin acts in the cytoplasm of neurons to regulate the availability of REST/NRSF to its nuclear NRSE-binding site and that this control is lost in the pathology of Huntington disease.
Journal ArticleDOI
Brain-derived neurotrophic factor in neurodegenerative diseases
Chiara Zuccato,Elena Cattaneo +1 more
TL;DR: The rationale for and discussed are the problems in proposing BDNF treatment as a beneficial and feasible therapeutic approach in the clinic, and the involvement of BDNF in a number of neurodegenerative diseases is reviewed.
Journal ArticleDOI
Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
TL;DR: The data that describe the emergence of the ancient huntingtin gene and of the polyglutamine trait during the last 800 million years of evolution are reviewed and data indicating how the loss of these beneficial activities reduces the ability of these neurons to survive are summarized.
Journal ArticleDOI
Normal huntingtin function: an alternative approach to Huntington's disease
TL;DR: There is considerable evidence that normal huntingtin is important for neuronal function and that the activity of some of its downstream effectors, such as brain-derived neurotrophic factor, is reduced in Huntington's disease.