Polysaccharide-based aerogels—Promising biodegradable carriers for drug delivery systems

High-pressure fluid phase equilibria

Cellulose-based aerogels

The interest of the use of supercritical fluids, especially supercritical CO2, for particle engineering over the last years has received attention from the pharmaceutical industry. Supercritical fluids can be used in different clean technologies to achieve high supersaturation, and consequently small crystalline particles with a narrow particle size distribution can be produced. This article aims to provide a compilation of old and new supercritical fluid as solvent or antisolvent techniques for drug processing and their fundamentals in terms of crystallization, thermodynamics and modelling results.

Supercritical fluids for pharmaceutical particle engineering: Methods, basic fundamentals and modelling

Vapor–liquid equilibria (VLE) data for the carbon dioxide + ethanol system at 293.15, 303.15, 313.15, 333.15, and 353.15 K up to 11.08 MPa are reported. The experimental method used in this work was a static-analytical method with liquid and vapor phase sampling. The new experimental results are discussed and compared with available literature data. Measured VLE data and literature data for carbon dioxide + ethanol system were modeled with a general cubic equation of state (GEOS) using classical van der Waals (two parameters conventional mixing rule—2PCMR) mixing rules. A single set of interaction parameters was used to calculate the global phase behavior in the binary mixture carbon dioxide + ethanol in a wide range of temperatures (283.3–453.15 K).

Ching-Ming Ko

Papers

Densities and P-x-y diagrams for carbon dioxide dissolution in methanol, ethanol, and acetone mixtures