C
Chinnaswamy Tiruppathi
Researcher at Albany Medical College
Publications - 11
Citations - 1093
Chinnaswamy Tiruppathi is an academic researcher from Albany Medical College. The author has contributed to research in topics: Endothelial stem cell & Thrombin. The author has an hindex of 8, co-authored 11 publications receiving 1066 citations.
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Journal ArticleDOI
Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.
TL;DR: An electrical method to study endothelial cell shape changes in real time in order to examine the mechanisms of alterations in the endothelial barrier function and provide insights into the signal-transduction events mediating the increased endothelial permeability is developed.
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Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion.
Y Sugama,Chinnaswamy Tiruppathi,K offakidevi,Thomas T. Andersen,John W. Fenton,Asrar B. Malik +5 more
TL;DR: Thrombin-induced endothelial adhesivity involves early- and late-phase responses, and the initial reversible PMN adhesion is mediated by rapid P-selectin expression via TRP-14 generation, which enables the interaction of ICAM-1 with the CD18 beta 2 integrin on PMN.
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Endothelin-1 stimulates DNA synthesis and proliferation of pulmonary artery smooth muscle cells.
Kilambi Janakidevi,M. A. Fisher,P. J. Del Vecchio,Chinnaswamy Tiruppathi,J. Figge,Asrar B. Malik +5 more
TL;DR: The results indicate that ET-1 under appropriate conditions can modulate the growth of pulmonary artery VSMC in both positive and negative directions.
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Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization.
Hazel Lum,Thomas T. Andersen,A. Siflinger-Birnboim,Chinnaswamy Tiruppathi,M. S. Goligorsky,John W. Fenton,Asrar B. Malik +6 more
TL;DR: It is suggested that combined cytosolic Ca2+ mobilization mediated by TRP-14 and PKC activation mediated by a TRp-14-independent pathway are dual signals responsible for the thrombin-induced increase in vascular endothelial permeability.
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Albumin and Ricinus communis agglutinin decrease endothelial permeability via interactions with matrix
TL;DR: This study studied the effects of albumin and the lectin Ricinus communis agglutinin (RCA) on hydraulic conductivity (Lp) of bovine pulmonary microvascular endothelial cell monolayers (BPMVEC) and determined the contribution of the extracellular matrix (ECM) in decreasing the Lp.