Phytochemical study of Capraria biflora L. aerial parts (Scrophulariaceae) from Martinique island (French West Indies)

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na v 1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Na v 1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

2-amino-n-heteroaryl-nicotinamides as nav1.8 inhibitors

The invention relates to a method for obtaining robinin-7-O-glucuronide through extraction and separation from Dracocephalum moldavica. The method is characterized by comprising the following steps: smashing the dry overground part of the Dracocephalum moldavica, obtaining a percolating solution through collection and extraction by adopting a percolating method, and obtaining a thick extract through vacuum concentration; and obtaining extract powder after water-bath drying. The extract powder is stirred by adopting a dry method after being dissolved with high concentration alcohol, polyamide column and ODS column chromatography is carried out, and after elution, an eluant is evaporated to dryness to obtain a white crystal, namely compound robinin-7-O-glucuronide, through a reduced pressure distillation device.

Preparation method of robinin-7-O-glucuronide

The invention provides a method for extracting acacetin-6-C-beta-D-glucopyranoside from Oxalis corniculata L.. The method comprises the following steps: extracting the Oxalis corniculata L. with waterto obtain Oxalis corniculata L. water extract, drying and crushing the Oxalis corniculata L. water extract to obtain powder, carrying out reduced pressure concentration through a rotary evaporator after the extraction to obtain ethyl acetate extract, and separating the ethyl acetate extract to obtain the acacetin-6-C-beta-D-glucopyranoside. When an effective component is separated from the Oxaliscorniculata L. extract through the method, the obtained effective component is highly pure, especially the purity of the acacetin-6-C-beta-D-glucopyranoside is 99% or more, the acacetin-6-C-beta-D-glucopyranoside can be used as an Oxalis corniculata L. monomer reference substance, and the development and the quality control of an Oxalis corniculata L. medicinal material and its preparation are facilitated.

Method for extracting acacetin-6-C-beta-D-glucopyranoside from Oxalis corniculata L.

The invention discloses application of robinin-7-O-glucuronide. A compound has cardioprotective effect activity, so that the robinin-7-O-glucuronide can be used as a lead compound with a cardioprotective effect.

Application of robinin-7-O-glucuronide

The present invention relates to a composition comprising acacetin-7-O-glucuronide or luteolin-7-O-glucuronide isolated from an extract of Chrysanthemum indicum showing tranquilizing activity to treat and prevent cerebrovascular system involved anxiety. The inventive compounds showed potent increasing effect on the time spent in open arm or closed arm and the number of open arm entries in elevated plus-maze test. Therefore it can be used as the therapeutics or health food for treating or preventing cerebrovascular system involved anxiety with safe.

A composition comprising the compound isolated from chrysanthemum indicum for treating or preventing cerebrovascular system involved anxiety and the use thereof

The present invention relates to a five-membered heterocyclic compound having an analgesic effect and a pharmaceutical composition comprising a derivative of the five-membered heterocyclic compound. More specifically, the present invention relates to a method for producing a five-membered heterocyclic compound having few side-effects and a broad analgesic effect, including pain relief for neuropathy, and to a pharmaceutical composition comprising the five-membered heterocyclic compound.

Choi Jong-Gil

Papers

A composition comprising the compound isolated from chrysanthemum indicum for treating or preventing cerebrovascular system involved anxiety and the use thereof

five-membered heterocyclic derivative, method for producing same, and pharmaceutical composition comprising same