Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Synthetic strategies for the generation of molecularly imprinted organic polymers.

Imprinted chiral stationary phases in high-performance liquid chromatography.

Recognition of oxytocin and oxytocin-related peptides in aqueous media using a molecularly imprinted polymer synthesized by the epitope approach.

A technique allowing high-throughput synthesis and evaluation of molecularly imprinted polymer sorbents at a reduced scale (mini-MIPs) was developed and used for the optimization of MIPs for use in pure aqueous environments. The technique incorporated a 4-port liquid-handling robot for the rapid dispensing of monomers, templates, solvents and initiator into the reaction vessels of a 96-well plate. A library of 80 polymers, each ca. 50 mg, could thus be prepared in 24 h. The MIP rebinding capacity and selectivity could be rapidly assessed in the batch mode by quantifying nonbound fractions in parallel using a UV monochromator plate reader. This allowed a complete evaluation of the binding characteristics of an 80 polymer library in approximately 1 week. With the objective of optimizing a polymer imprinted with the local anaesthetic Bupivacaine for use in pure aqueous systems, a polymer library was prepared by varying the original poly(MAA-co-EDMA) MIP composition. The variable factors were the added amount...

Water-Compatible Molecularly Imprinted Polymers Obtained via High-Throughput Synthesis and Experimental Design

Influence of template basicity and hydrophobicity on the molecular recognition properties of molecularly imprinted polymers

Molecular imprinting in network polymers under high pressure was studied as a means of inducing selective binding sites for molecular recognition. Network polymers of methacrylic acid and ethylene ...

Christian Dauwe

Papers

Influence of template basicity and hydrophobicity on the molecular recognition properties of molecularly imprinted polymers

Pressure-Induced Binding Sites in Molecularly Imprinted Network Polymers