The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.

Novel anti-IL 13 antibodies and uses thereof

The present application describes antibodies that selectively bind human FcgammaRIIB, with little or no binding to other human FcgammaRs, e.g., human FcgammaRIIA. The invention also provides isolated bispecific antibodies comprising an antibody that selectively binds FcgammaRIIB, and a second antibody that specifically binds an activating receptor. Various uses, including therapeutic uses, for those antibodies are also described, including administration with anti-tumor antibodies and methods of inhibiting immune responses and suppressing histamine release.

Anti-FC-gamma RIIB receptor antibody and uses therefor

The present invention relates to longitudinally sectioned bullets and more particularly pertains to a projectile (10) structured to be discharged from a firearm and comprising at least two separable longitudinal body sections (60) (80) and at least one binding element (110) that holds the at least two longitudinal body sections together, such as before impact with a target. Said projectile is thus capable of controlled fragmentation against a soft target. Said projectile is adapted to also contain at least one supplemental payload (230) deliverable to a target.

Longitudinally sectioned firearms projectiles

An airborne spin dispensing apparatus (100,101) and method of dispensing a plurality of sub-units (60) such that the ground plane impact pattern of the plurality of sub-units substantially corresponds to a particular geometric ground target. An onboard microprocessor (24) which receives flight data (26) and a selected target data (28) also has a program store of sub-unit ejection sequences each of which corresponds to a particular target impact geometry. The microprocessor (24) selects an appropriate sub-unit ejection sequence in accordance with the flight and selected target data and effects a release of the sub-units (60) from the spinning apparatus such that their ground impact pattern substantially matches the geometry of the ground target.

Spin dispensing method and apparatus

Missile (10) includes one or more of barrel assemblies (11) which are displaced from the centre of gravity of missile (10). Each barrel assembly (11) includes a plurality of projectiles axially disposed within the barrel, and each projectiles is associated with a discrete propellant charge for propelling the projectile sequentially from the barrel. Each array of barrel assemblies (11) is capable of selectively firing the projectiles from selected barrels whereby missile (10) is accelerated by the reactionary force generated by said firing of projectiles and the missile is deflected onto a new course or trajectory. This enables missile (10) to be steered to intercept its target even if the target is undertaking evasive manoeuvre. Each barrel assembly (11) can include up to twelve projectiles.

Directional control of missiles

There is disclosed a missile which automatically disintegrates after a predetermined flight time. The missile is made up of several parts which are positively secured together by a locking means which is released at a predetermined time after the firing of the missile by the action of the air through which the missile passes during its flight. The invention may by used to advantage in both practice missiles and service missiles.

Automatically disintegrating missile

In the method and apparatus for covering a target area with ammunition, a container, which contains active bodies W arranged on different decks 30.1, 30.2 and which is to be brought over the target area, releases the active bodies W through release openings 34 on its sides to become effective from above on respective individual flight paths against objects, for example armored vehicles, present in the target area.

Method and apparatus for covering a target area with ammunition

Verfahren und vorrichtung zum belegen einer zielflaeche mit munition

There is described a spin stabilized projectile assembly including a projectile, a sabot, and a guide ring. The projectile is provided with a shoulder at the rear end of which abuts the sabot, the projectile and sabot being connected by the guide ring which extends around the projectile and part of the sabot. The guide ring is arranged so that after the projectile assembly has been fired and has left the barrel of the weapon the sabot and the projectile separate. The sabot has a diameter substantially equal to that of the projectile; the guide ring is secured to the sabot against relative movement in a longitudinal direction but is rotatable with respect to the sabot.

Christian Dipl Ing Dr Jaeneke

Papers

Automatically disintegrating missile

Method and apparatus for covering a target area with ammunition

Verfahren und vorrichtung zum belegen einer zielflaeche mit munition

Spin stabilized projectile assembly

Geschoss mit selbsttaetiger zerlegerwirkung