C
Christian M. Hackeng
Researcher at Utrecht University
Publications - 74
Citations - 3660
Christian M. Hackeng is an academic researcher from Utrecht University. The author has contributed to research in topics: Clopidogrel & Platelet. The author has an hindex of 26, co-authored 71 publications receiving 3486 citations. Previous affiliations of Christian M. Hackeng include Erasmus University Rotterdam.
Papers
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Journal ArticleDOI
Comparison of Platelet Function Tests in Predicting Clinical Outcome in Patients Undergoing Coronary Stent Implantation
Nicoline J. Breet,Jochem W. van Werkum,Heleen J. Bouman,Johannes C. Kelder,Henk J.T. Ruven,Egbert T. Bal,Vera H.M. Deneer,Ankie M. Harmsze,Jan Van der Heyden,Benno J. Rensing,Maarten J. Suttorp,Christian M. Hackeng,Jurriën M. ten Berg +12 more
TL;DR: Of the platelet function tests assessed, light transmittance aggregometry, Verify Now, Platelet works, and Innovance PFA P2Y were significantly associated with the primary end point, however, the predictive accuracy of these 4 tests was only modest.
Journal ArticleDOI
Paraoxonase-1 is a major determinant of clopidogrel efficacy
Heleen J. Bouman,Edgar Schömig,Jochem W. van Werkum,Janna Velder,Christian M. Hackeng,Christoph Hirschhäuser,Christopher M. Waldmann,Hans-Günther Schmalz,Jurriën M. ten Berg,Dirk Taubert +9 more
TL;DR: Using in vitro metabolomic profiling techniques, paraoxonase-1 (PON1) is identified as the crucial enzyme for clopidogrel bioactivation, with its common Q192R polymorphism determining the rate of active metabolite formation.
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Impaired bioavailability of clopidogrel in patients with a ST-segment elevation myocardial infarction.
A. A. C. M. Heestermans,Jochem W. van Werkum,Dirk Taubert,Toine H. Seesing,Nicolas von Beckerath,Christian M. Hackeng,Edgar Schömig,Freek W.A. Verheugt,Jurriën M. ten Berg +8 more
TL;DR: This poster presents a probabilistic study of the response of the immune system to certain types of heart attacks in patients with a history of cardiopulmonary disease.
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CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case–control study
Ankie M. Harmsze,Jochem W. van Werkum,Jurriën M. ten Berg,Bastiaan Zwart,Heleen J. Bouman,Nicoline J. Breet,Arnoud W J van 't Hof,Hendrik J.T. Ruven,Christian M. Hackeng,Olaf H. Klungel,Anthonius de Boer,Vera H.M. Deneer +11 more
TL;DR: In this paper, the effect of variations in genes involved in the absorption (ABCB1 C1236T, G2677T/A, C3435T), metabolism (CYP2C19*2 and *3, CYP2C9*2, *3*, CYP3A4*1B and *5*3), and pharmacodynamics (P2Y1 A1622G) of clopidogrel on the occurrence of stent thrombosis was determined.
Journal ArticleDOI
A head-to-head comparison between the VerifyNow P2Y12 assay and light transmittance aggregometry for monitoring the individual platelet response to clopidogrel in patients undergoing elective percutaneous coronary intervention.
J. W. Van Werkum,C. A. K. Van Der Stelt,Toine H. Seesing,Christian M. Hackeng,J. M. ten Berg +4 more
TL;DR: The platelet response to clopidogrel (and aspirin) in 211 consecutive patients undergoing elective PCI with stenting was prospectively studied and absolute P2Y12 Reaction Units (PRUs) were preferred over reported BASE values of the VerifyNow P2y12 assay in the present study.