Showing papers by "Christian Sell published in 2009"
TL;DR: The results suggest that an enhanced ability to bind to DNA ends may be important for longevity, and a number of possible roles for increased levels of Ku and DNA-PKcs are discussed.
64 citations
TL;DR: These results show for the first time a link between INTS6/DICE1 function, cell cycle regulation and cell-cell communication involving members of the Wnt signaling pathway.
Abstract: The gene encoding integrator complex subunit 6 (INTS6), previously known as deleted in cancer cells 1 (DICE1, OMIM 604331) was found to be frequently affected by allelic deletion and promoter hypermethylation in prostate cancer specimens and cell lines. A missense mutation has been detected in prostate cancer cell line LNCaP. Together, these results suggest INTS6/DICE1 as a putative tumor suppressor gene in prostate cancer. In this study, we examined the growth inhibitory effects of INTS6/DICE1 on prostate cancer cells. Markedly decreased INTS6/DICE1 mRNA levels were detected in prostate cancer cell lines LNCaP, DU145 and PC3 as well as CPTX1532 as compared to a cell line derived from normal prostate tissue, NPTX1532. Exogenous re-expression of INTS6/DICE1 cDNA in androgen-independent PC3 and DU145 cell lines substantially suppressed their ability to form colonies in vitro. This growth inhibition was not due to immediate induction of apoptosis. Rather, prostate cancer cells arrested in G1 phase of the cell cycle. Expression profiling of members of the Wnt signaling pathway revealed up-regulation of several genes including disheveled inhibitor CXXC finger 4 (CXXC4), frizzled homologue 7 (FZD7), transcription factor 7-like 1 (TCF7L1), and down-regulation of cyclin D1. These results show for the first time a link between INTS6/DICE1 function, cell cycle regulation and cell-cell communication involving members of the Wnt signaling pathway.
34 citations
TL;DR: In this article, the effects of insulin-like growth factor type 1 (IGF-I) on total protein oxidation in brain tissues and in cell cultures were studied. And the results indicate that in frontal cortex the level of oxidized proteins is significantly reduced in transgenic mice designed to overproduce IGF-I compared with wild-type animals.
22 citations
Book•
01 Jan 2009
TL;DR: Exploiting Natural Variation in Life Span To Evaluate Mechanisms of Aging and Slow aging from An Exceptionally Long-Lived Rodent, the Naked Mole-Rat.
Abstract: Reprogramming Cell Survival and Longevity: The role of Tor, Sch9, Ras, and Sir2.- Common Aging Mechanisms: Energy Metabolism and Longevity in Caenorhabditis elegans.- Conserved Mechanisms of Life-Span Regulation and Extension in Caenorhabditis elegans.- Drosophila melanogaster.- Overview of the Genetic Architecture of Longevity.- Mild Stress and Life Extension in Drosophila melanogaster.- Rodents.- Global Food Restriction.- Growth Hormone and Aging in Mice.- Comparative Biology of Aging.- Exploiting Natural Variation in Life Span To Evaluate Mechanisms of Aging.- Slow aging: Insights from An Exceptionally Long-Lived Rodent, the Naked Mole-Rat.- Life Extension in the Short-lived Fish Nothobranchius furzeri.- Aging in Humans.- Aging and Longevity in Animal Models and Humans.- Human aging and longevity within an evolutionary perspective.
8 citations