C
Christian Zscherp
Researcher at Goethe University Frankfurt
Publications - 11
Citations - 2033
Christian Zscherp is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Infrared spectroscopy & Spectroscopy. The author has an hindex of 6, co-authored 11 publications receiving 1857 citations.
Papers
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Journal ArticleDOI
What vibrations tell us about proteins
Andreas Barth,Christian Zscherp +1 more
TL;DR: This review deals with current concepts of vibrational spectroscopy for the investigation of protein structure and function, namely the amide I vibration of the polypeptide backbone that is used for secondary-structure analysis and some of the general aspects also apply to RamanSpectroscopy.
Journal ArticleDOI
Reaction-induced infrared difference spectroscopy for the study of protein reaction mechanisms.
Christian Zscherp,Andreas Barth +1 more
TL;DR: This technique enables detailed characterization of enzyme function on the level of single bonds of proteins, cofactors, or substrates and Illustrating applications are given including hot topics from the fields of bioenergetics, protein folding, and molecule--protein interaction.
Patent
Infrared measuring device, especially for the spectrometry of aqueous systems, preferably multiple component systems
Werner Maentele,Oliver Klein,Christian Zscherp,Andreas Barth,Hermann von Lilienfeld-Toal,Hellmuth Von Prollius,Frithjof Von Germar,Heribert Offermanns +7 more
TL;DR: In this paper, an infrared measuring device for the spectrometry of aqueous systems is described, which comprises at least one measuring unit, especially a measuring cell, also comprising at least two planar, substantially parallel limiting surfaces and which is transparent with respect to measuring radiation and which has an index of refraction which is greater than that of the medium which is arranged next to at least 1.5.
Journal ArticleDOI
Substrate binding and enzyme function investigated by infrared spectroscopy.
Andreas Barth,Christian Zscherp +1 more
TL;DR: It is shown that infrared spectroscopy provides valuable information on general aspects of enzyme function as well as on molecular details of molecule–protein interactions and the mechanism of catalysis.
Journal ArticleDOI
Effect of proline to alanine mutation on the thermal stability of the all-β-sheet protein tendamistat
TL;DR: Evaluation of data from different infrared (IR) bands sensitive to changes in secondary structure as well as toChanges in tertiary structure strongly supports a two-state model for the unfolding process of wild-type tendamistat.