Showing papers by "Christina Wang published in 1978"
TL;DR: It is suggested that secretions of LH were increased during surgery and that that of T were decreased post‐operatively, resulting in a compensatory elevation of LH concentrations.
Abstract: SUMMARY
The effect of surgical stress on the secretions of LH, FSH, testosterone (T) and oestradiol (E2) were studied in twelve male patients. During surgery LH rose significantly; post-operatively, LH fell but remained persistently elevated a week after operation. However, T and E2 fell progressively to a nadir on the second and fifth post-operative day respectively and remained suppressed. Serum FSH showed no significant change. Despite a post-operative decrease in sex hormone binding globulin (SHBG) binding capacity, non-SHBG bound T showed a decrease parallel to T. Multiple sampling studies showed that the secretions of LH were increased and that of T were decreased post-operatively. Following surgery, LH responses to LHRH were magnified, FSH and T responses showed no significant change when compared with the pre-operative responses. These data suggest that secretions of LH were increased during surgery. Following surgical stress, T and E2 concentrations were suppressed resulting in a compensatory elevation of LH concentrations.
108 citations
TL;DR: The data suggest that following the medical stress of myocardial infarction, testosterone concentration was suppressed resulting in a compensatory rise in LH.
Abstract: SUMMARY
The effect of acute myocardial infarction on the secretions of LH, FSH and testosterone was studied in thirteen male patients. Plasma testosterone fell transiently on the fourth day after acute myocardial infarction. This was accompanied by a rise in LH on the same day which persisted for a week after infarction. Serum FSH showed no significant change. The data suggest that following the medical stress of myocardial infarction, testosterone concentration was suppressed resulting in a compensatory rise in LH.
102 citations
TL;DR: The effect of heroin addiction on pituitary‐testicular function was studied in 54 active and 19 abstinent addicts and their results were compared with those of 43 age‐matched controls.
Abstract: The effect of heroin addiction on pituitary-testicular function was studied in 54 active and 19 abstinent addicts and their results were compared with those of 43 age-matched controls. Abnormal sexual function was frequently found in heroin addicts and this persisted after drug withdrawal. The mean total (mean +/- SE, 18.1 +/- 1.0 nmol/1) and free (0.17 +/- 0.03 nmol/1) testosterone (T) levels in heroin addicts were significantly lower than those in healthy controls (total T 22.8 +/- 1.1 nmol/1), P less than 0.005; free T 0.30 +/- 0.03 nmol/1, P less than 0.005). The mean sex hormone binding globulin binding capacity was higher in heroin addicts (60.1 +/- 5.2 mM) than in healthy controls (35.5 +/- 2.1 mM). These hormonal changes returned promptly to normal after withdrawal. The basal LH and FSH and the responses to LHRH were comparable in the three groups studied. The finding of significantly lower total and free T together with higher SHBG indicates an abnormal testicular function in heroin addiction. Normal basal and LHRH-stimulated LH and FSH levels suggest that chronic heroin abuse depressed testicular function via the hypothalamus or higher centres.
101 citations
TL;DR: The effect of surgery on pituitary-thyroid function was studied in 12 euthyroid patients, with a sharp early increase in total thyroxine level, causing displacement of triiodothyronine from thyroid hormone binding proteins resulting in the elevation of the biologically more potent free triiodoryronine fraction.
Abstract: The effect of surgery on pituitary-thyroid function was studied in 12 euthyroid patients. There was a sharp early increase in total thyroxine level, causing displacement of triiodothyronine from thyroid hormone binding proteins resulting in the elevation of the biologically more potent free triiodothyronine fraction. The serum triiodothyronine concentration fell rapidly during and after the operation, with a concomitant rise in reverse triiodothyronine level. Increased prolactin levels were found during and after surgery. With no post-operative complication, recovery of normal pituitary-thyroid function occurred after 4 to 7 days of convalescence.
36 citations
TL;DR: The findings indicate that this uncommon cause of medically-controllable juvenile hypertension can be identified without specific steroid assays.
Abstract: Summary: Hypertension due to 17α-hydroxylase deficiency.
A female patient with hypertension, hypogonadism and hypokalemia due to 17α-hydroxylase deficiency is described, in whom the diagnosis was initially based on the finding of low urinary 17-ketosteroids and 17-hydroxycorticosteroids, in the presence of high plasma f/uorometric 11-hydroxy -corticoids. Later studies confirmed the diagnosis by demonstrating low circulating levels of 17u-hydroxyprogesterone and the steroids derived from this precursor: 11-deoxy-cortisol, Cortisol, oestradiol and testosterone. Plasma progesterone, corticosterone and deoxycorticosterone (DOC) were greatly increased, but plasma and urine aldosterone were very low. The initial subnormal Cortisol and 11-deoxyCortisol levels responded to tetracosactrin administration, suggesting that the adrenal was not maximally stimulated by endogenous ACTH and indicating that the 17α-hydroxylase deficiency was incomplete. Plasma and urinary aldosterone levels were still suppressed after 12 months treatment with prednisone despite normalization of the previously suppressed renin levels. The findings indicate that this uncommon cause of medically-controllable juvenile hypertension can be identified without specific steroid assays.
5 citations