Showing papers by "Christine C. Winterbourn published in 2018"

TL;DR: The utility of R19-S for detecting HOCl in real-time is confirmed and definitive evidence that isolated neutrophils produce HO Cl in phagosomes is provided, suggesting that the intriguing variability in the onset of HOCl production among phagosome identified here could influence the way they kill ingested bacteria.

TL;DR: This study identified constitutive interaction partners of Prx2 in Jurkat T‐lymphoma cells, in which thiol protein oxidation occurs at low micromolar concentrations of H2O2, and suggested a cell‐type specific mechanism to increase the sensitivity of CRMP2 to oxidation.

TL;DR: Staphyloxanthin may protect some bacterial strains against oxidative killing by neutrophils, but enterobactin will not inhibit the production of hypochlorous acid.

TL;DR: HBr is produced by peroxidasin in the extracellular matrix and appears to be directed at the site of collagen IV sulfilimine formation but the released HOBr may also undergo other reactions.

TL;DR: It is observed that Saccharomyces cerevisiae strains lacking either copper-zincSOD (SOD1) or manganese SOD ( SOD2) had decreased RNR activity compared to SOD-competent yeast, which demonstrates that protection of RNR from inactivation by superoxide is an important function of SOD, particularly cytoplasmic SOD1.

TL;DR: It is found that HCO3- with H2O2 together potently overcomes TrxR1- and Trx1 -mediated protection of PTP1B and that its subsequent reactivation is dependent upon Prx2, where H 2O2 clearance becomes a key regulatory event.