C
Christine Xue
Researcher at University of California, Los Angeles
Publications - 6
Citations - 460
Christine Xue is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Fibril & Thioflavin. The author has an hindex of 5, co-authored 6 publications receiving 292 citations.
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Journal ArticleDOI
Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation.
TL;DR: It is shown that ThT fluorescence correlates linearly with amyloid concentration over ThT concentrations ranging from 0.2 to 500 µM, which could affect the shape of the aggregation curves, but this effect is protein-dependent and not universal.
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Aβ42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism.
TL;DR: It is shown that Aβ42 spontaneously forms oligomers with a wide range of sizes in the same sample, and results suggest that the fibrils formed by larger oligomers may adopt a different structure from fibrILS formed by smaller oligomers, pointing to a link between oligomer heterogeneity and fibril polymorphism.
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Polymorphic Aβ42 fibrils adopt similar secondary structure but differ in cross-strand side chain stacking interactions within the same β-sheet.
TL;DR: The data suggest that cross-strand side chain packing interactions within the same β-sheet may play a critical role in the formation of polymorphic fibrils.
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A mix-and-click method to measure amyloid-β concentration with sub-micromolar sensitivity
TL;DR: It is shown that, using hen egg white lysozyme as a standard, fluorescence correlates linearly with primary amine concentration across a wide range of fluorescamine concentrations, from 62.5 to 1000 µM.
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Site-specific structural order in Alzheimer's Aβ42 fibrils.
TL;DR: In the context of recent structural work using solid-state NMR and cryoEM, the site-specific structural order revealed in this study provides a different perspective on backbone and side chain dynamics of Aβ42 fibrils.