C
Christof Hiebel
Researcher at University of Mainz
Publications - 11
Citations - 446
Christof Hiebel is an academic researcher from University of Mainz. The author has contributed to research in topics: Proteostasis & BAG3. The author has an hindex of 9, co-authored 11 publications receiving 370 citations.
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Journal ArticleDOI
Protein homeostasis, aging and Alzheimer's disease.
TL;DR: Since aging is accompanied by changes in cellular protein homeostasis and an increasing demand for protein degradation, aspects of protein folding, misfolding, refolding and, importantly, protein degradation need to be linked to AD pathogenesis.
Journal ArticleDOI
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy.
Natalie Spang,Anne Feldmann,Heike Huesmann,Fazilet Bekbulat,Verena Schmitt,Christof Hiebel,Ingrid Koziollek-Drechsler,Albrecht M. Clement,Bernd Moosmann,Jennifer Jung,Christian Behrends,Ivan Dikic,Andreas Kern,Christian Behl +13 more
TL;DR: RAB3GAP1/2 is identified as novel conserved factors of the autophagy and proteostasis network and is analyzed in relation to the previously reported suppressive Autophagy modulators FEZ1 and FEZ2 and demonstrate that both reciprocally regulate autophileagy.
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Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function.
Vanessa Felzen,Christof Hiebel,Ingrid Koziollek-Drechsler,S Reißig,Uwe Wolfrum,Donat Kögel,C Brandts,Christian Behl,Tobias Morawe +8 more
TL;DR: A novel non-canonical autophagy pathway is uncovers that might be an interesting target for personalized medicine and treatment of ERα-positive breast cancer cells that do not respond to anti-hormone therapy and classical Autophagy inhibitors.
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Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis.
Rebecca Reilly,Magdalena S. Mroz,Eugene M. Dempsey,Kieran Wynne,Stephen J. Keely,Edward F. McKone,Christof Hiebel,Christian Behl,Judith A. Coppinger,Judith A. Coppinger +9 more
TL;DR: The most effective inhibitor, MK-2206 exerted a rescue effect by restoring autophagy in ΔF508 CFBE41o- cells, and the potential of the PI3K/Akt/mTOR pathway for therapeutic targeting in CF is demonstrated.
Journal ArticleDOI
Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition
Christoph Stumm,Christof Hiebel,Regina Hanstein,Martin Purrio,Heike Nagel,Andrea Conrad,Beat Lutz,Christian Behl,Angela B. Clement +8 more
TL;DR: It is indicated that CB1 deficiency can worsen AD-related cognitive deficits and support a potential role of CB1 as a pharmacologic target.