Christoph Hutzler

TL;DR: The data demonstrate the necessity of standardized machine smoking protocols to reliably address putative risks of e-cigarettes for consumers and the formation of carbonylic compounds in one widely distributed nicotine-free brand.

TL;DR: This study confirms that levels of major carcinogens are markedly reduced in the emissions of the analyzed HNB product in relation to the conventional tobacco cigarettes and that monitoring these emissions using standardized machine smoking procedures generates reliable and reproducible data which provide a useful basis to assess exposure and human health risks.

TL;DR: Previous assessments of HTPs are briefly summarized, including a short discussion on challenges with the adaption of standard analytical methods used for tobacco smoke, and challenges regarding a classification in Europe are discussed briefly.

TL;DR: The data demonstrate that the metabolic capacity of human skin ex vivo, as well as organotypic human 3D skin models toward BP, is sufficient to cause significant genotoxic stress and thus cutaneous bioactivation may potentially contribute to mutations that ultimately lead to skin cancer.

TL;DR: For the first time, pyrolysis-GC/MS is introduced as method suitable to simulate pigment fragmentation that may occur spontaneously or during laser removal of organic pigments in the living skin of tattooed people.