Christoph Weiler

TL;DR: Histologic disc alterations can reliably be graded based on the proposed classification system providing a morphologic framework for more sophisticated molecular biologic analyses of factors leading to age-related disc changes.

TL;DR: Its occurrence in adults of more advanced age suggests that tumor necrosis factor; is not involved in the initiation of disc degeneration, but may be associated with further promotion of degenerative disarrangement and pain induction.

TL;DR: The data suggest that major MMPs play an important role in the degradation of the IVD, evidenced by the high correlation of MMP expression with the formation of clefts and tears, and implicate a leading function for M MPs in IVD degeneration resulting in the loss of normal disc function, eventually leading to low-back pain.

TL;DR: Data on the gene and protein level is provided, which highlights the key role of MMP-3 in the degenerative cascade leading to symptomatic disc degeneration and herniation and Control of the proteolytic activity of M MP-3 may, therefore, come into the focus when aiming to develop new treatment options for earlyDisc degeneration.

TL;DR: IDO in endothelial cells might limit the influx of tryptophan from the blood to the tumor or generate tumor-toxic metabolites, thus restricting tumor growth and contributing to survival.