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Christoph Weiler
Researcher at Ludwig Maximilian University of Munich
Publications - 34
Citations - 2994
Christoph Weiler is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Intervertebral disc & Carcinoma. The author has an hindex of 21, co-authored 34 publications receiving 2733 citations.
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Journal ArticleDOI
Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science.
Norbert Boos,Sabine Weissbach,Helmut Rohrbach,Christoph Weiler,Kevin F. Spratt,Andreas G. Nerlich +5 more
TL;DR: Histologic disc alterations can reliably be graded based on the proposed classification system providing a morphologic framework for more sophisticated molecular biologic analyses of factors leading to age-related disc changes.
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Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls.
TL;DR: Its occurrence in adults of more advanced age suggests that tumor necrosis factor; is not involved in the initiation of disc degeneration, but may be associated with further promotion of degenerative disarrangement and pain induction.
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2002 SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption.
TL;DR: The data suggest that major MMPs play an important role in the degradation of the IVD, evidenced by the high correlation of MMP expression with the formation of clefts and tears, and implicate a leading function for M MPs in IVD degeneration resulting in the loss of normal disc function, eventually leading to low-back pain.
Journal ArticleDOI
Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration
Beatrice E. Bachmeier,Andreas G. Nerlich,Norbert Mittermaier,Christoph Weiler,Christianto Lumenta,Karin Wuertz,Norbert Boos +6 more
TL;DR: Data on the gene and protein level is provided, which highlights the key role of MMP-3 in the degenerative cascade leading to symptomatic disc degeneration and herniation and Control of the proteolytic activity of M MP-3 may, therefore, come into the focus when aiming to develop new treatment options for earlyDisc degeneration.
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Expression of Indoleamine 2,3-Dioxygenase in Tumor Endothelial Cells Correlates with Long-term Survival of Patients with Renal Cell Carcinoma
Rainer Riesenberg,Christoph Weiler,Oliver Spring,Martin Eder,Alexander Buchner,Tanja Popp,Mirna Castro,Robert Kammerer,Osamu Takikawa,Rudolf Hatz,Christian G. Stief,Alfons Hofstetter,Wolfgang Zimmermann +12 more
TL;DR: IDO in endothelial cells might limit the influx of tryptophan from the blood to the tumor or generate tumor-toxic metabolites, thus restricting tumor growth and contributing to survival.