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Christopher J. Yehl
Researcher at Pennsylvania State University
Publications - 6
Citations - 79
Christopher J. Yehl is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Countercurrent exchange & Diafiltration. The author has an hindex of 3, co-authored 6 publications receiving 42 citations.
Papers
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Journal ArticleDOI
Single-use, single-pass tangential flow filtration using low-cost hollow fiber modules
TL;DR: Results clearly demonstrate the potential of using commercially available hollow fiber membranes, originally designed for high-flux hemodialysis, for single pass tangential flow filtration with high conversions in continuous biomanufacturing.
Journal ArticleDOI
Multistage continuous countercurrent diafiltration for formulation of monoclonal antibodies
TL;DR: The objective of this study was to design and test a three‐stage countercurrent DF system that could achieve at least 99.9% buffer exchange over 24 hr of continuous operation and provide important insights to the design and operation of a continuous process for antibody formulation.
Journal ArticleDOI
Hollow fiber countercurrent dialysis for continuous buffer exchange of high-value biotherapeutics
TL;DR: The results clearly demonstrate the potential of using low‐cost hollow fiber dialyzers for buffer exchange and product formulation in continuous bioprocessing.
Journal ArticleDOI
High Performance Countercurrent Membrane Purification for protein separations
TL;DR: The results demonstrate the feasibility of using HPCMP for high resolution separations in the preparation of biopharmaceuticals and natural protein products.
Journal ArticleDOI
Characterization of dextran transport and molecular weight cutoff (MWCO) of large pore size hollow fiber ultrafiltration membranes
TL;DR: In this article, a combination of experimental measurements and theoretical modeling is used to develop an improved methodology for evaluating the MWCO of these large pore size ultrafiltration membranes based on dextran retention measurements.