C
Christopher Lugo
Researcher at Princeton University
Publications - 1
Citations - 8
Christopher Lugo is an academic researcher from Princeton University. The author has contributed to research in topics: Viral replication & Replicon. The author has an hindex of 1, co-authored 1 publications receiving 8 citations.
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Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance
Angela M. Lam,Thomas E. Edwards,Ralph T. Mosley,Eisuke Murakami,Shalini Bansal,Christopher Lugo,Haiying Bao,Michael J. Otto,Michael J. Sofia,Phillip A. Furman +9 more
TL;DR: A crystal structure of the NS5B S15G/C223H/V321I mutant of the JFH-1 isolate exhibited rearrangement to a conformation potentially consistent with short primer-template RNA binding, which could suggest a mechanism of resistance accomplished through a change in theNS5B conformation, which was better tolerated by genotype 2a virus than by viruses of other genotypes.