C
Christopher M. Olsen
Researcher at Medical College of Wisconsin
Publications - 42
Citations - 1498
Christopher M. Olsen is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Nucleus accumbens & Traumatic brain injury. The author has an hindex of 19, co-authored 36 publications receiving 1290 citations. Previous affiliations of Christopher M. Olsen include Vanderbilt University & Veterans Health Administration.
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Journal ArticleDOI
Natural rewards, neuroplasticity, and non-drug addictions.
TL;DR: Exposure to non-drug rewards can alter neural plasticity in regions of the brain that are affected by drugs of abuse, and repeated exposure to natural rewards might induce neuroplasticity that either promotes or counteracts addictive behavior.
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Serotonergic Neurotoxic Metabolites of Ecstasy Identified in Rat Brain
Douglas C. Jones,Christine L. Duvauchelle,Aiko Ikegami,Christopher M. Olsen,Christopher M. Olsen,Serrine S. Lau,Rafael de la Torre,Terrence J. Monks +7 more
TL;DR: The data support the contention that MDMA-mediated serotonergic neurotoxicity is mediated by the systemic formation of GSH and N-acetylcysteine conjugates of N-methyl-α-MeDA (and α-Me DA).
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Extracellular-Signal Regulated Kinase 1-Dependent Metabotropic Glutamate Receptor 5-Induced Long-Term Depression in the Bed Nucleus of the Stria Terminalis Is Disrupted by Cocaine Administration
Brad A. Grueter,Heather B. Gosnell,Christopher M. Olsen,Nicole L. Schramm-Sapyta,Tanya Nekrasova,Gary E. Landreth,Danny G. Winder +6 more
TL;DR: A role for this form of plasticity in the actions of psychostimulants on anxiety and reward circuitries and their emergent control of animal behavior is suggested.
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Cholinergic interneurons of the nucleus accumbens and dorsal striatum are activated by the self-administration of cocaine.
Monica L. Berlanga,Christopher M. Olsen,V. Chen,Aiko Ikegami,Bruce E. Herring,Christine L. Duvauchelle,Adriana A. Alcantara +6 more
TL;DR: It is demonstrated that cholinergic interneurons are involved in the initial stage of cocaine intake and that these neurons are located in areas of the nucleus accumbens and dorsal striatum that are more closely tied to the rewarding and hedonic effects rather than the motor effects of cocaine Intake.
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Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice.
TL;DR: This study found that C57Bl/6J mice readily acquired operant responding for dynamic visual stimuli, a phenomenon the authors term operant sensation seeking (OSS), and found that OSS, like psychostimulant self-administration, is sensitive to disruption of dopamine signaling.