C
Christopher Yu
Researcher at Genentech
Publications - 8
Citations - 193
Christopher Yu is an academic researcher from Genentech. The author has contributed to research in topics: Chemistry & Quality (philosophy). The author has an hindex of 5, co-authored 6 publications receiving 116 citations.
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Journal ArticleDOI
A View on the Importance of “Multi-Attribute Method” for Measuring Purity of Biopharmaceuticals and Improving Overall Control Strategy
Richard S. Rogers,Michael J. Abernathy,Douglas D. Richardson,Jason C. Rouse,Justin B. Sperry,Patrick Swann,Jette Wypych,Christopher Yu,Li Zang,Rohini Deshpande +9 more
TL;DR: A liquid chromatography-mass spectrometry (LC-MS) multi-attribute method (MAM) has been developed and designed for improved simultaneous detection, identification, quantitation, and quality control (monitoring) of molecular attributes.
Journal ArticleDOI
Investigating interactions between phospholipase B-Like 2 and antibodies during Protein A chromatography.
Benjamin Tran,Vanessa Grosskopf,Xiangdan Wang,Jihong Yang,Donald E. Walker,Christopher Yu,Paul J. Mcdonald +6 more
TL;DR: The results showed that the co-elution of PLBL2 during Protein A chromatography is highly dependent on the individual antibody andPLBL2 concentration in the chromatographic load, and there is a preference for PLBL 2 to interact with IgG4 subclass antibodies compared to IgG1 antibodies.
Journal ArticleDOI
Evaluation of Heavy-Chain C-Terminal Deletion on Product Quality and Pharmacokinetics of Monoclonal Antibodies
Guoying Jiang,Christopher Yu,Daniela Bumbaca Yadav,Zhilan Hu,Annamarie Amurao,Eileen T. Duenas,Marc Wong,Mark Iverson,Kai Zheng,Xanthe M. Lam,Jia Chen,Roxanne Vega,Sheila Ulufatu,Cecilia Leddy,Helen Davis,Amy Shen,Pin Y. Wong,Reed J. Harris,Y. John Wang,Dongwei Li +19 more
TL;DR: This study provides a possible solution to mitigate mAb heterogeneity in C-terminal processing, improve batch-to-batch consistency, and facilitate the comparability study during process changes.
Journal ArticleDOI
Multi-attribute method performance profile for quality control of monoclonal antibody therapeutics.
Zhiqi Hao,Benjamin Moore,Chengfeng Ren,Monica Sadek,Frank Macchi,Lindsay Yang,Jack Harris,Laura Yee,Emily Liu,Vanessa Tran,Milady R. Niñonuevo,Chen Yan,Christopher Yu +12 more
TL;DR: In this article, a multi-attribute method (MAM) using peptide map analysis with high resolution mass spectrometry is used for product characterization and the identification of critical quality attributes (CQAs) of biotherapeutic proteins.
Journal ArticleDOI
Evaluation of Heavy Chain C-terminal Deletions on Productivity and Product Quality of Monoclonal Antibodies in Chinese Hamster Ovary (CHO) Cells.
Zhilan Hu,Danming Tang,Shahram Misaghi,Guoying Jiang,Christopher Yu,Mandy Yim,David E. Shaw,Brad Snedecor,Michael W. Laird,Amy Shen +9 more
TL;DR: While no measurable differences in antibody HC and LC mRNA levels, glycosylation and secretion were observed, the analysis suggests that the lower specific productivity of clones expressing antibody lacking HC C‐terminal lysine was due to slower antibody HC synthesis and faster antibody degradation.