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Chunyuan Chen
Researcher at Nanchang University
Publications - 3
Citations - 348
Chunyuan Chen is an academic researcher from Nanchang University. The author has contributed to research in topics: Induced pluripotent stem cell & Mesenchymal stem cell. The author has an hindex of 3, co-authored 3 publications receiving 236 citations.
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Journal ArticleDOI
Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway.
Jieyuan Zhang,Xiaolin Liu,Haiyan Li,Chunyuan Chen,Bin Hu,Xin Niu,Qing Li,Bizeng Zhao,Zongping Xie,Yang Wang +9 more
TL;DR: Results indicate that naturally secreted nanocarriers-exosomes can be used as a bioactive material to improve the bioactivity of the biomaterials, and that hiPS-MSC-Exos combined with β-TCP scaffolds can be potentially used for repairing bone defects.
Journal ArticleDOI
Dimethyloxaloylglycine Promotes the Angiogenic Activity of Mesenchymal Stem Cells Derived from iPSCs via Activation of the PI3K/Akt Pathway for Bone Regeneration.
Jieyuan Zhang,Junjie Guan,Xin Qi,Hao Ding,Hong Yuan,Zongping Xie,Chunyuan Chen,Xiaolin Li,Changqing Zhang,Yigang Huang +9 more
TL;DR: Evaluation of the effect of DMOG on promoting hiPSC-MSCs angiogenesis in tissue-engineered bone and the underlying mechanisms in vitro indicate that DMOG, via activation of the PI3K/Akt pathway, promotes the angiogenic of hiPSc- MSCs in tissue’s for bone defect repair and thatDMOG-treated hiPSCs can be exploited as a potential therapeutic tool in bone regeneration.
Journal ArticleDOI
Inhibition of Notch signaling facilitates the differentiation of human-induced pluripotent stem cells into neural stem cells
TL;DR: Inhibition of Notch signaling accelerated the formation of the neural rosette structures and the expression of NSC and mature neurocyte marker genes, suggesting that notch signaling negatively regulated the neuralization of human iPSCs, and that this process may be regulated by some miRNAs.