C
Claudia König
Publications - 2
Citations - 312
Claudia König is an academic researcher. The author has contributed to research in topics: Heterologous expression & Stereospecificity. The author has an hindex of 2, co-authored 2 publications receiving 266 citations.
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Journal ArticleDOI
Targeting DnaN for tuberculosis therapy using novel griselimycins
Angela Kling,Peer Lukat,Deepak V. Almeida,Armin Bauer,Evelyne Fontaine,Sylvie Sordello,Nestor Zaburannyi,Jennifer Herrmann,Silke C. Wenzel,Claudia König,Nicole C. Ammerman,María Belén Barrio,Kai Borchers,Florence Bordon-Pallier,Mark Brönstrup,Courtemanche Gilles,Martin Gerlitz,Michel Geslin,Peter Hammann,Dirk W. Heinz,Holger Hoffmann,Sylvie Klieber,Markus Kohlmann,Michael Kurz,Christine Lair,Hans Matter,Eric L. Nuermberger,Sandeep Tyagi,Laurent Fraisse,Jacques H. Grosset,Sophie Lagrange,Rolf Müller +31 more
TL;DR: It is shown that new optimized derivatives from Streptomyces-derived griselimycin are highly active against M. tuberculosis, both in vitro and in vivo, by inhibiting the DNA polymerase sliding clamp DnaN.
Journal ArticleDOI
Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.
Peer Lukat,Yohei Katsuyama,Silke C. Wenzel,Tina M. Binz,Claudia König,Wulf Blankenfeldt,Mark Brönstrup,Rolf Müller +7 more
TL;DR: The biosynthesis of griselimycins in Streptomyces DSM 40835 and the pathway that stereospecifically converts l-leucine to (2S,4R)-4-methyl-proline are reported by means of biochemical and structural analysis.