Showing papers by "Clive Wood published in 2011"
Patent•
27 Jan 2011
TL;DR: In this article, the authors identify PD-1 as a receptor of B7-4, which can inhibit the activation of an immunocyte when it is bonded to an inhibitory receptor on an immuneocyte.
Abstract: PROBLEM TO BE SOLVED: To provide an agent which modulates a signaling via PD-1. SOLUTION: PD-1 is identified as a receptor of B7-4. B7-4 can inhibit the activation of an immunocyte when it is bonded to an inhibitory receptor on an immunocyte. Therefore, modulation of immune response is induced by modulating costimulatory or inhibitory signal of the immunocyte by administrating an agent which modulates PD-1, B7-4 and interaction between B7-4 and PD-1. COPYRIGHT: (C)2011,JPO&INPIT