C
Csaba Szegedi
Researcher at Hungarian Academy of Sciences
Publications - 18
Citations - 656
Csaba Szegedi is an academic researcher from Hungarian Academy of Sciences. The author has contributed to research in topics: Ryanodine receptor & Calcium. The author has an hindex of 13, co-authored 18 publications receiving 626 citations. Previous affiliations of Csaba Szegedi include University of Debrecen.
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Journal ArticleDOI
Calsequestrin: More than 'only' a luminal Ca2+ buffer inside the sarcoplasmic reticulum
TL;DR: It is shown that, depending on its phosphorylation state, calsequestrin selectively controls the RyR channel activity at 1 mM free luminal [Ca2+], and solely dephosphorylated calsequer regulates Ca2+ release from the SR.
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Delineation of Myotoxicity Induced by 3-Hydroxy-3-methylglutaryl CoA Reductase Inhibitors in Human Skeletal Muscle Cells
TL;DR: It is shown that statins cause apoptosis in differentiated human skeletal muscle cells, delineate the signaling cascade that leads to muscle injury caused by statins and have implications for improving the safety of this important medication.
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Effects of Dantrolene on Steps of Excitation-Contraction Coupling in Mammalian Skeletal Muscle Fibers
Péter Szentesi,Claude Collet,Sándor Sárközi,Csaba Szegedi,Istvan Jona,Vincent Jacquemond,László Kovács,László Csernoch +7 more
TL;DR: Dantrolene was found to suppress the depolarization-induced elevation in intracellular calcium concentration ([Ca2+]i) by inhibiting the release of calcium from the SR by binding on the SR membrane, but be distinct from the purified RYR itself.
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Modulation of sarcoplasmic reticulum function by Na+/K+ pump inhibitors with different toxicity: digoxin and PST2744 [(E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride].
Marcella Rocchetti,Alessandra Besana,Gaspare Mostacciuolo,Rosella Micheletti,Patrizia Ferrari,Sándor Sárközi,Csaba Szegedi,Istvan Jona,Antonio Zaza +8 more
TL;DR: The more favorable inotropy-to-toxicity ratio previously described for PST2744 appears to be associated with direct SERCA stimulation and/or lack of enhancement of Ca2+ leak.
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Surface plasmon resonance studies prove the interaction of skeletal muscle sarcoplasmic reticular Ca2+ release channel/ryanodine receptor with calsequestrin
TL;DR: A high affinity molecular interaction is demonstrated between calsequestrin and the sarcoplasmic reticular Ca2+ release channel/ryanodine receptor (RyR) by surface plasmon resonance.