Cuihua Zhang

TL;DR: Recent evidence showing the role of TNF-α in vascular dysfunction in cardiovascular disease is summarized and it is believed these findings may prompt new directions for targeting inflammation in future therapies.

TL;DR: It is proposed that SIRT1, via a pathway that involves the upregulation of eNOS, induces mitochondrial biogenesis in endothelial cells via activating SIRT 1, and the potential for new treatment approaches targeting endothelial mitochondria in metabolic diseases is suggested.

TL;DR: The focus of this review is to summarize recent evidence showing the effects of inflammation on vascular dysfunction in ischemic-heart disease, which may prompt new directions for targeting inflammation in future therapies.

TL;DR: The results demonstrate the endothelial dysfunction occurring in the metabolic syndrome is the result of effects of the inflammatory cytokine TNF-&agr; and subsequent production of &OV0151;.

TL;DR: In this paper, the authors investigated the effect of resveratrol on mtROS production in cultured human coronary arterial endothelial cells (CAECs) and found that reserveratrol attenuates both steady-state and high glucose (30 mM)-induced mtRos production in CAECs, an effect that was prevented by the knockdown of the protein deacetylase silent information regulator 2/sirtuin 1 (SIRT1), an intracellular target of reserver atrin 1.