D
D. Cowfer
Researcher at Genentech
Publications - 2
Citations - 266
D. Cowfer is an academic researcher from Genentech. The author has contributed to research in topics: Glycoprotein & Chinese hamster ovary cell. The author has an hindex of 1, co-authored 1 publications receiving 263 citations.
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Journal ArticleDOI
Engineering Chinese hamster ovary cells to maximize sialic acid content of recombinant glycoproteins.
S. Weikert,Damon I. Papac,J. Briggs,D. Cowfer,S. Tom,Martin Gawlitzek,J. Lofgren,S. Mehta,Vanessa Chisholm,Nishit B. Modi,S. Eppler,K. Carroll,Steven M. Chamow,David H. Peers,Phillip W. Berman,Lynne A. Krummen +15 more
TL;DR: The experiments demonstrate the feasibility of genetically engineering cell lines to produce therapeutics with desired glycosylation patterns and resulted in reduction of oligosaccharides terminating with GlcNAc, whereas overexpression of ST resulted in sialylation of ≥90% of available branches.
Journal ArticleDOI
Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro
Sheli R. Radoshitzky,Patrick L. Iversen,Xianghan Lu,Jing Zou,Suzanne J.F. Kaptein,Kelly S. Stuthman,Sean A. Van Tongeren,Jesse T. Steffens,Ruoyu Gong,Hoa Truong,Annapurna A. Sapre,Huiling Yang,X. Xie,Jia Jun Chia,Zhijuan Song,Stacey M. Leventhal,Josolyn Chan,Alex Shornikov,Xin Zhang,D. Cowfer,Travis K. Warren,Tomas Cihlar,Danielle P. Porter,Johan Neyts,Pei Yong Shi,Jay Wells,John P. Bilello,Joy Y. Feng +27 more
TL;DR: Remdesivir (GS-5734; VEKLURY) is a single diastereomer monophosphoramidate prodrug of an adenosine analog as discussed by the authors .