Antikinetoplastid activity of 3-aryl-5-thiocyanatomethyl-1,2,4-oxadiazoles

The hydrazinolysis reaction of 5-perfluoroalkyl-1,2,4-oxadiazoles has been investigated. Nucleophilic addition of the reagent to the C(5)−N(4) double bond of the oxadiazole ring, followed by ring-opening and then ring-closure involving the β-nitrogen atom of the hydrazino moiety and the C(3) of the oxadiazole ring, explains the formation of 5-perfluoroalkyl-1,2,4-triazoles as final products. Useful applications in synthesis of this uncommon hydrazinolysis can be claimed.

Fluorinated heterocyclic compounds. An expedient route to 5-perfluoroalkyl-1,2,4-triazoles via an unusual hydrazinolysis of 5-perfluoroalkyl-1,2,4-oxadiazoles: first examples of an ANRORC-like reaction in 1,2,4-oxadiazole derivatives.

In the present article synthesis and medicinal applications of [1, 2, 4] oxadiazoles are reviewed. The oxadiazoles have a wide range of applications such as Antitussive, Anti-inflammatory, Anaesthetic, Vasodilator, anthelmintic, antiallergic, antiplatelet effects in vitro, antithrombotic properties in vivo, etc. Many researchers have synthesized novel heterocyclic compounds containing oxadiazoles with the concept of bioisosterism.

[1, 2, 4]-Oxadiazoles: Synthesis and Biological Applications

A photochemical generation of nitrosocarbonyl intermediates

Roberto Ballini,† Noelia Arauj́o,‡ María V. Gil, Emilio Romań,* and Jose ́ A. Serrano †School of Science and Technology, Chemistry Division, via S. Agostino 1, I-62032 Camerino, Italy ‡Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom Departamento de Química Orgańica e Inorgańica, Facultad de Ciencias, Universidad de Extremadura, 06071 Badajoz, Spain

D. L. Heywood

Papers

Synthesis and microbial toxicity of dinitrobutadienes and related compounds

The Acylation of Benzamidoximes

Reaction of "activated" esters with amidoximes. Convenient synthesis of 1,2,4-oxadiazoles

Synth. und mikrobielle toxizitaet von dinitrobutadienen und verwandten verbindungen